Simultaneous Detection of Distinct Ubiquitin Chain Topologies by 19F NMR

The dynamic interplay between ubiquitin (Ub) chain construction and destruction is critical for the regulation of many cellular pathways. To understand these processes, it would be ideal to simultaneously detect different Ub chains as they are created and destroyed in the cell. This objective cannot...

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Veröffentlicht in:	ACS chemical biology 2014-10, Vol.9 (10), p.2229-2236
Hauptverfasser:	Shekhawat, Sujan S, Pham, Grace H, Prabakaran, Jyothiprashanth, Strieter, Eric R
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluorine - chemistry Letters Magnetic Resonance Spectroscopy - methods Models, Molecular Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination
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