Connexin31.1 (Gjb5) Deficiency Blocks Trophoblast Stem Cell Differentiation and Delays Placental Development

The gap junction channel forming connexins (Cx) Cx31 ( Gjb3 ) and Cx31.1 ( Gjb5 ) are co-expressed in the mouse trophoblast lineage. Inactivation of either gene results in partial embryonic loss at mid gestation (60% and 30%, respectively, between embryonic days E10.5and E13.5) caused by placental p...

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Veröffentlicht in:	Stem cells and development 2014-11, Vol.23 (21), p.2649-2660
Hauptverfasser:	Kibschull, Mark, Colaco, Keith, Matysiak-Zablocki, Elzbieta, Winterhager, Elke, Lye, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Proliferation - genetics Cells, Cultured Connexin 26 Connexins - deficiency Connexins - genetics Connexins - metabolism Cyclin-Dependent Kinase Inhibitor p57 - genetics Cyclin-Dependent Kinase Inhibitor p57 - metabolism Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Female Gene Expression Regulation, Developmental Immunohistochemistry In Situ Hybridization Male Mice, Inbred C57BL Mice, Knockout Original Research Reports Placenta - embryology Placenta - metabolism Pregnancy Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Trophoblasts - cytology Trophoblasts - metabolism
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