Combined Endothelin A Blockade and Chlorthalidone Treatment in a Rat Model of Metabolic Syndrome

Experiments determined whether the combination of endothelin A (ETA) receptor antagonist [ABT-627, atrasentan; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid] and a thiazide diuretic (chlorthalidone) would be more effective at low...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-11, Vol.351 (2), p.467-473
Hauptverfasser:	Jin, Chunhua, Jeon, Yejoo, Kleven, Daniel T., Pollock, Jennifer S., White, John J., Pollock, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Arterial Pressure - drug effects Cell Adhesion Molecules - metabolism Chlorthalidone - pharmacology Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Disease Models, Animal Diuretics - pharmacology Drug Combinations Drug Discovery and Translational Medicine Endothelin A Receptor Antagonists Endothelins - antagonists & inhibitors Endothelins - metabolism Hypertension - drug therapy Hypertension - metabolism Inflammation - drug therapy Inflammation - metabolism Kidney Diseases - drug therapy Kidney Diseases - metabolism Male Membrane Proteins - metabolism Metabolic Syndrome - drug therapy Metabolic Syndrome - metabolism Oxidative Stress - drug effects Proteinuria - drug therapy Proteinuria - metabolism Pyrrolidines - pharmacology Rats Rats, Inbred Dahl Rats, Sprague-Dawley Receptor, Endothelin A - metabolism Sodium Chloride, Dietary - adverse effects
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