γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

Activity-dependent CREB phosphorylation and gene expression are critical for long-term neuronal plasticity. Local signaling at CaV1 channels triggers these events, but how information is relayed onward to the nucleus remains unclear. Here, we report a mechanism that mediates long-distance communicat...

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Veröffentlicht in:	Cell 2014-10, Vol.159 (2), p.281-294
Hauptverfasser:	Ma, Huan, Groth, Rachel D., Cohen, Samuel M., Emery, John F., Li, Boxing, Hoedt, Esthelle, Zhang, Guoan, Neubert, Thomas A., Tsien, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Channels - metabolism calcium-calmodulin-dependent protein kinase Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin - metabolism Cell Nucleus - metabolism Cyclic AMP Response Element-Binding Protein - metabolism gene expression Neurons - metabolism neuroplasticity Phosphorylation Rats, Sprague-Dawley Transcription, Genetic
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