Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition

Elevated Src kinase in epithelial cancer cells induces adhesion changes that are associated with a mesenchymal-like state. We recently showed that Src induces dynamic integrin adhesions in KM12C colon cancer cells, whereas E-cadherin-dependent cell-cell contacts become disorganized. This promotes a...

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Veröffentlicht in:	Molecular biology of the cell 2004-06, Vol.15 (6), p.2794-2803
Hauptverfasser:	Avizienyte, Egle, Fincham, Valerie J, Brunton, Valerie G, Frame, Margaret C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cadherins - metabolism Cell Adhesion - drug effects Cell Differentiation Cell Line, Tumor Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Epithelial Cells - cytology Epithelial Cells - metabolism Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Humans Integrins - metabolism MAP Kinase Signaling System Mesoderm - cytology Mesoderm - metabolism Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism Myosins - metabolism Phosphorylation Point Mutation Proto-Oncogene Proteins pp60(c-src) - chemistry Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - metabolism Serum src Homology Domains Transfection Vimentin - metabolism
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