Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

The non-essential amino acid, glutamine, exerts pleiotropic effects on cell metabolism, signalling and stress resistance. Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, inter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2014-09, Vol.5 (1), p.4900-4900, Article 4900
Hauptverfasser:	Shanware, Naval P., Bray, Kevin, Eng, Christina H., Wang, Fang, Follettie, Maximillian, Myers, Jeremy, Fantin, Valeria R., Abraham, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/89 14 14/63 38 631/67 631/80/86 82/58 Amino acids Autophagy Biosynthesis Cancer Carbon Cell growth Cell Line, Tumor Chemokines Citric Acid Cycle Endoplasmic reticulum Endoplasmic Reticulum Stress Gene expression Glucose Glutamine Humanities and Social Sciences Humans Interleukin-8 - metabolism Kinases Lipids Lysosomes - metabolism MAP Kinase Kinase 4 - genetics MAP Kinase Kinase 4 - metabolism Mechanistic Target of Rapamycin Complex 1 Metabolism Mitochondria multidisciplinary Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Oncology Proteins R&D Research & development Science Science (multidisciplinary) Senescence TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!