The sodium channel β1 subunit mediates outgrowth of neurite‐like processes on breast cancer cells and promotes tumour growth and metastasis

Voltage‐gated Na+ channels (VGSCs) are heteromeric proteins composed of pore‐forming α subunits and smaller β subunits. The β subunits are multifunctional channel modulators and are members of the immunoglobulin superfamily of cell adhesion molecules (CAMs). β1, encoded by SCN1B, is best characteriz...

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Veröffentlicht in:	International journal of cancer 2014-11, Vol.135 (10), p.2338-2351
Hauptverfasser:	Nelson, Michaela, Millican‐Slater, Rebecca, Forrest, Lorna C., Brackenbury, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Adult Aged Aged, 80 and over Animals Apoptosis Blotting, Western Breast - metabolism breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Biology Cell Proliferation Female fyn kinase Humans Immunoenzyme Techniques Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary metastasis Mice Mice, Nude Middle Aged Neurites - metabolism Neurites - pathology Neurons - metabolism Neurons - pathology Proto-Oncogene Proteins c-fyn - genetics Proto-Oncogene Proteins c-fyn - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured Voltage-Gated Sodium Channel beta-1 Subunit - genetics Voltage-Gated Sodium Channel beta-1 Subunit - metabolism voltage‐gated Na+ channel Xenograft Model Antitumor Assays
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