Nuclear Matrix Protein SMAR1 Represses c-Fos-mediated HPV18 E6 Transcription through Alteration of Chromatin Histone Deacetylation

Matrix attachment region (MAR)-binding proteins have been implicated in the transcriptional regulation of host as well as viral genes, but their precise role in HPV-infected cervical cancer remains unclear. Here we show that HPV18 promoter contains consensus MAR element in the LCR and E6 sequences w...

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Veröffentlicht in:	The Journal of biological chemistry 2014-10, Vol.289 (42), p.29074-29085
Hauptverfasser:	Chakraborty, Samik, Das, Kaushik, Saha, Shilpi, Mazumdar, Minakshi, Manna, Argha, Chakraborty, Sreeparna, Mukherjee, Shravanti, Khan, Poulami, Adhikary, Arghya, Mohanty, Suchismita, Chattopadhyay, Samit, Biswas, Subhash C., Sa, Gaurisankar, Das, Tanya
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Apoptosis Cell Biology Cell Cycle Proteins - metabolism Chromatin - metabolism DNA-Binding Proteins - metabolism Gene Expression Regulation, Viral HeLa Cells Histones - metabolism Humans Nuclear Proteins - metabolism Oncogene Proteins, Viral - metabolism Promoter Regions, Genetic Protein Binding Proto-Oncogene Proteins c-fos - metabolism Transcription Factor AP-1 - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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