Decoding ChIP-seq with a double-binding signal refines binding peaks to single-nucleotides and predicts cooperative interaction

The comprehension of protein and DNA binding in vivo is essential to understand gene regulation. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) provides a global map of the regulatory binding network. Most ChIP-seq analysis tools focus on identifying binding regions from coverage en...

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Veröffentlicht in:	Genome research 2014-10, Vol.24 (10), p.1686-1697
Hauptverfasser:	Gomes, Antonio L C, Abeel, Thomas, Peterson, Matthew, Azizi, Elham, Lyubetskaya, Anna, Carvalho, Luís, Galagan, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Binding Sites Chromatin Immunoprecipitation Computational Biology - methods DNA-Binding Proteins - metabolism Method Models, Genetic Nucleotides - metabolism Sequence Analysis, DNA
Online-Zugang:	Volltext
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