Association of the interleukin-22 genetic polymorphisms with ulcerative colitis
Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of...
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| Veröffentlicht in: | Diagnostic pathology 2014-10, Vol.9 (1), p.183-183, Article 183 |
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| creator | Chi, Hong Gang Zheng, Xue Bao Wu, Zhu Guo Dai, Shi Xue Wan, Zheng Zou, Ying |
| description | Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.
This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).
Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) =1.35, 4.37; P=0.003] and -429 T allele (OR =1.54, 95% CI=1.14, 2.07; P=0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22+1046 T/A and IL-22+1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.
This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183. |
| doi_str_mv | 10.1186/s13000-014-0183-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4198677</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A540640566</galeid><sourcerecordid>A540640566</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-ede8d6456b039059a4f04f45d8db2ffb89d6f0fb9272c08c6ae34d29988cbd433</originalsourceid><addsrcrecordid>eNqNUk2PFCEUJEbjrqs_wIvpxIuXXoEGGi4mk41fySZ70TPpph8zrDSMQK-Zfy-dWTezxoMhhBeoKt6rFEKvCb4kRIr3mXQY4xYTVrfs2sMTdE56JlrClXh6Up-hFznfYsw4p_g5OqOcql70_Tm62eQcjRuKi6GJtik7aFwokDwsP1xoKW22EKA40-yjP8wx7Xcuz7n55cquWbyBVLl30JjoXXH5JXpmB5_h1f15gb5_-vjt6kt7ffP569XmujWc9qWFCeQkGBcj7hTmamAWM8v4JKeRWjtKNQmL7ahoTw2WRgzQsYkqJaUZJ9Z1F-jDUXe_jDNMBkJJg9f75OYhHXQcnH78EtxOb-OdZkTJOnkVeHcvkOLPBXLRs8sGvB8CxCVrImQvaodc_AeUdIrVKVSFvv0LehuXFKoTK4oK2jN2gtoOHrQLNtYWzSqqN5xhUbXE-u3lP1B1TTA7EwNYV-8fEciRYFLMOYF9sINgvQZGHwOja2D0Ghh9qJw3pz4-MP4kpPsN9Yy7kg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1612627449</pqid></control><display><type>article</type><title>Association of the interleukin-22 genetic polymorphisms with ulcerative colitis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Chi, Hong Gang ; Zheng, Xue Bao ; Wu, Zhu Guo ; Dai, Shi Xue ; Wan, Zheng ; Zou, Ying</creator><creatorcontrib>Chi, Hong Gang ; Zheng, Xue Bao ; Wu, Zhu Guo ; Dai, Shi Xue ; Wan, Zheng ; Zou, Ying</creatorcontrib><description>Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.
This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).
Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) =1.35, 4.37; P=0.003] and -429 T allele (OR =1.54, 95% CI=1.14, 2.07; P=0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22+1046 T/A and IL-22+1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.
This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183.</description><identifier>ISSN: 1746-1596</identifier><identifier>EISSN: 1746-1596</identifier><identifier>DOI: 10.1186/s13000-014-0183-y</identifier><identifier>PMID: 25297677</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Case-Control Studies ; Colitis, Ulcerative - genetics ; Female ; Gene Frequency ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Humans ; Inflammatory bowel disease ; Interleukin-22 ; Interleukins ; Interleukins - genetics ; Male ; Medical research ; Medicine, Experimental ; Odds Ratio ; Polymorphism, Single Nucleotide ; Studies</subject><ispartof>Diagnostic pathology, 2014-10, Vol.9 (1), p.183-183, Article 183</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Chi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Chi et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-ede8d6456b039059a4f04f45d8db2ffb89d6f0fb9272c08c6ae34d29988cbd433</citedby><cites>FETCH-LOGICAL-c527t-ede8d6456b039059a4f04f45d8db2ffb89d6f0fb9272c08c6ae34d29988cbd433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198677/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198677/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25297677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chi, Hong Gang</creatorcontrib><creatorcontrib>Zheng, Xue Bao</creatorcontrib><creatorcontrib>Wu, Zhu Guo</creatorcontrib><creatorcontrib>Dai, Shi Xue</creatorcontrib><creatorcontrib>Wan, Zheng</creatorcontrib><creatorcontrib>Zou, Ying</creatorcontrib><title>Association of the interleukin-22 genetic polymorphisms with ulcerative colitis</title><title>Diagnostic pathology</title><addtitle>Diagn Pathol</addtitle><description>Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.
This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).
Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) =1.35, 4.37; P=0.003] and -429 T allele (OR =1.54, 95% CI=1.14, 2.07; P=0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22+1046 T/A and IL-22+1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.
This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183.</description><subject>Adult</subject><subject>Analysis</subject><subject>Case-Control Studies</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Interleukin-22</subject><subject>Interleukins</subject><subject>Interleukins - genetics</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Studies</subject><issn>1746-1596</issn><issn>1746-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNUk2PFCEUJEbjrqs_wIvpxIuXXoEGGi4mk41fySZ70TPpph8zrDSMQK-Zfy-dWTezxoMhhBeoKt6rFEKvCb4kRIr3mXQY4xYTVrfs2sMTdE56JlrClXh6Up-hFznfYsw4p_g5OqOcql70_Tm62eQcjRuKi6GJtik7aFwokDwsP1xoKW22EKA40-yjP8wx7Xcuz7n55cquWbyBVLl30JjoXXH5JXpmB5_h1f15gb5_-vjt6kt7ffP569XmujWc9qWFCeQkGBcj7hTmamAWM8v4JKeRWjtKNQmL7ahoTw2WRgzQsYkqJaUZJ9Z1F-jDUXe_jDNMBkJJg9f75OYhHXQcnH78EtxOb-OdZkTJOnkVeHcvkOLPBXLRs8sGvB8CxCVrImQvaodc_AeUdIrVKVSFvv0LehuXFKoTK4oK2jN2gtoOHrQLNtYWzSqqN5xhUbXE-u3lP1B1TTA7EwNYV-8fEciRYFLMOYF9sINgvQZGHwOja2D0Ghh9qJw3pz4-MP4kpPsN9Yy7kg</recordid><startdate>20141009</startdate><enddate>20141009</enddate><creator>Chi, Hong Gang</creator><creator>Zheng, Xue Bao</creator><creator>Wu, Zhu Guo</creator><creator>Dai, Shi Xue</creator><creator>Wan, Zheng</creator><creator>Zou, Ying</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20141009</creationdate><title>Association of the interleukin-22 genetic polymorphisms with ulcerative colitis</title><author>Chi, Hong Gang ; 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IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.
This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).
Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) =1.35, 4.37; P=0.003] and -429 T allele (OR =1.54, 95% CI=1.14, 2.07; P=0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22+1046 T/A and IL-22+1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.
This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25297677</pmid><doi>10.1186/s13000-014-0183-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Case-Control Studies Colitis, Ulcerative - genetics Female Gene Frequency Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype Humans Inflammatory bowel disease Interleukin-22 Interleukins Interleukins - genetics Male Medical research Medicine, Experimental Odds Ratio Polymorphism, Single Nucleotide Studies |
| title | Association of the interleukin-22 genetic polymorphisms with ulcerative colitis |
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