UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

UBL5 is an atypical ubiquitin‐like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre‐mRNA splicing efficiency,...

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Veröffentlicht in:	EMBO reports 2014-09, Vol.15 (9), p.956-964
Hauptverfasser:	Oka, Yasuyoshi, Varmark, Hanne, Vitting-Seerup, Kristoffer, Beli, Petra, Waage, Johannes, Hakobyan, Anna, Mistrik, Martin, Choudhary, Chunaram, Rohde, Mikkel, Bekker-Jensen, Simon, Mailand, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Cell Cycle Proteins - genetics Cellular biology Chromatids - genetics Chromosome Segregation - genetics Chromosomes Cohesion EMBO06 EMBO36 Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Regulation Genes Genomics HeLa Cells Humans Ligases - genetics Mass spectrometry Mitosis - genetics pre-mRNA splicing Proteins Retention Ribonucleic acid RNA RNA Precursors - genetics RNA Splicing - genetics Saccharomyces cerevisiae Proteins - genetics Scientific Report Scientific Reports sister chromatid cohesion sororin Spliceosomes - genetics ubiquitin-like protein Ubiquitins - genetics Ubiquitins - metabolism UBL5 Yeasts
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