Mapping the Shh long-range regulatory domain

Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms. The Shh gene and well-established regulators are an example of genomic composition in which enhancers reside in a large dese...

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Veröffentlicht in:	Development (Cambridge) 2014-10, Vol.141 (20), p.3934-3943
Hauptverfasser:	Anderson, Eve, Devenney, Paul S, Hill, Robert E, Lettice, Laura A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - cytology DNA Transposable Elements Enhancer Elements, Genetic Gene Expression Profiling Gene Expression Regulation, Developmental Genes, Reporter Genetic Complementation Test Hedgehog Proteins - genetics Hedgehog Proteins - physiology Heterozygote Introns Mice Mice, Transgenic Models, Genetic Promoter Regions, Genetic Protein Structure, Tertiary Transgenes
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