Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of genes that control cell identity and repression of genes encoding lineage-specifying developmental regulators. Here, we use ESC cohesin ChIA-PET data to identify the local chromosomal structures at both activ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2014-10, Vol.159 (2), p.374-387
Hauptverfasser:	Dowen, Jill M., Fan, Zi Peng, Hnisz, Denes, Ren, Gang, Abraham, Brian J., Zhang, Lyndon N., Weintraub, Abraham S., Schuijers, Jurian, Lee, Tong Ihn, Zhao, Keji, Young, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCCTC-Binding Factor Cell Cycle Proteins - metabolism Chromatin Immunoprecipitation Chromosomal Proteins, Non-Histone - metabolism chromosomes Chromosomes, Mammalian - metabolism Cohesins embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism genes Genome High-Throughput Nucleotide Sequencing mammals Mice Organ Specificity Pluripotent Stem Cells - metabolism Repressor Proteins - metabolism Sequence Analysis, DNA transcription (genetics)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!