Executive control circuitry differentiates degree of success in weight loss following gastric‐bypass surgery
Objective While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric‐bypass surgery, the degree of weight loss can be differentiated based on the...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2013-11, Vol.21 (11), p.2189-2196 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Goldman, Rachel L. Canterberry, Melanie Borckardt, Jeffrey J. Madan, Alok Byrne, T. Karl George, Mark S. O'Neil, Patrick M. Hanlon, Colleen A. |
| description | Objective
While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric‐bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues.
Design and Methods
In this functional MRI study, 31 post‐surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to “crave” or to “resist” craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss.
Results
Overall, instructions to “crave” elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas “resist” elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to “crave.” The more successful participants however had significantly more activity in the DLPFC when instructed to “resist.”
Conclusions
These findings suggest that the ability to mobilize neural circuits involved in executive control post‐gastric‐bypass surgery may be a unique component of successful outcome post‐surgery. |
| doi_str_mv | 10.1002/oby.20575 |
| format | Article |
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While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric‐bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues.
Design and Methods
In this functional MRI study, 31 post‐surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to “crave” or to “resist” craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss.
Results
Overall, instructions to “crave” elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas “resist” elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to “crave.” The more successful participants however had significantly more activity in the DLPFC when instructed to “resist.”
Conclusions
These findings suggest that the ability to mobilize neural circuits involved in executive control post‐gastric‐bypass surgery may be a unique component of successful outcome post‐surgery.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20575</identifier><identifier>PMID: 24136926</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Addictions ; Addictive behaviors ; Adult ; Aged ; Behavior ; Brain research ; Eating disorders ; Executive Function - physiology ; Female ; Food ; Gastric Bypass ; Gastrointestinal surgery ; Heart surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motivation ; Nerve Net - physiology ; Neural networks ; Obesity ; Obesity, Morbid - diagnosis ; Obesity, Morbid - physiopathology ; Obesity, Morbid - psychology ; Obesity, Morbid - surgery ; Postoperative Period ; Prognosis ; Studies ; Success ; Surgical outcomes ; Treatment Outcome ; Weight control ; Weight Loss ; Young Adult</subject><ispartof>Obesity (Silver Spring, Md.), 2013-11, Vol.21 (11), p.2189-2196</ispartof><rights>Copyright © 2013 The Obesity Society</rights><rights>Copyright © 2013 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Nov 2013</rights><rights>2013 The Obesity Society 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4095-3e3cb14d4b4bbbed403574ff68beef874e9992d6ba8a8eea33149ba54c5530453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20575$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20575$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24136926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldman, Rachel L.</creatorcontrib><creatorcontrib>Canterberry, Melanie</creatorcontrib><creatorcontrib>Borckardt, Jeffrey J.</creatorcontrib><creatorcontrib>Madan, Alok</creatorcontrib><creatorcontrib>Byrne, T. Karl</creatorcontrib><creatorcontrib>George, Mark S.</creatorcontrib><creatorcontrib>O'Neil, Patrick M.</creatorcontrib><creatorcontrib>Hanlon, Colleen A.</creatorcontrib><title>Executive control circuitry differentiates degree of success in weight loss following gastric‐bypass surgery</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric‐bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues.
Design and Methods
In this functional MRI study, 31 post‐surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to “crave” or to “resist” craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss.
Results
Overall, instructions to “crave” elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas “resist” elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to “crave.” The more successful participants however had significantly more activity in the DLPFC when instructed to “resist.”
Conclusions
These findings suggest that the ability to mobilize neural circuits involved in executive control post‐gastric‐bypass surgery may be a unique component of successful outcome post‐surgery.</description><subject>Addictions</subject><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Aged</subject><subject>Behavior</subject><subject>Brain research</subject><subject>Eating disorders</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Food</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motivation</subject><subject>Nerve Net - physiology</subject><subject>Neural networks</subject><subject>Obesity</subject><subject>Obesity, Morbid - diagnosis</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - psychology</subject><subject>Obesity, Morbid - surgery</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Studies</subject><subject>Success</subject><subject>Surgical outcomes</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctO3DAUtapWBQYW_ACy1E03A3b8SLypVBC0lZDYgAQry3ZugpEnntoJ0-z6Cf3GfkldoKO2m_vQOTr3XB2EDik5poRUJ9HOxxURtXiFdqliZFkzdft6Ozd0B-3l_EAIl0TQt2in4pRJVcldNJx_AzeN_hGwi8OYYsDOJzf5Mc249V0HCYbRmxEybqFPADh2OE_OQc7YD3gDvr8fcYhl7WIIceOHHvcmj8m7n99_2HltCpSn1EOa99GbzoQMBy99gW4uzq_PPi8vrz59Oft4uXScKLFkwJylvOWWW2uh5YSJmnedbCxA19QclFJVK61pTANgGKNcWSO4E4IRLtgCfXjWXU92Ba0rPyQT9Dr5lUmzjsbrf5HB3-s-PmpOlZSKFoH3LwIpfp0gj3rls4MQzABxypoKwssdomShvvuP-hCnNJT3NJU1rxlrSlmgo78dba38iaIQTp4JGx9g3uKU6N8Z65KxfspYX53ePQ3sFxCdncc</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Goldman, Rachel L.</creator><creator>Canterberry, Melanie</creator><creator>Borckardt, Jeffrey J.</creator><creator>Madan, Alok</creator><creator>Byrne, T. Karl</creator><creator>George, Mark S.</creator><creator>O'Neil, Patrick M.</creator><creator>Hanlon, Colleen A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201311</creationdate><title>Executive control circuitry differentiates degree of success in weight loss following gastric‐bypass surgery</title><author>Goldman, Rachel L. ; Canterberry, Melanie ; Borckardt, Jeffrey J. ; Madan, Alok ; Byrne, T. Karl ; George, Mark S. ; O'Neil, Patrick M. ; Hanlon, Colleen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4095-3e3cb14d4b4bbbed403574ff68beef874e9992d6ba8a8eea33149ba54c5530453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Addictions</topic><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Aged</topic><topic>Behavior</topic><topic>Brain research</topic><topic>Eating disorders</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Food</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motivation</topic><topic>Nerve Net - physiology</topic><topic>Neural networks</topic><topic>Obesity</topic><topic>Obesity, Morbid - diagnosis</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - psychology</topic><topic>Obesity, Morbid - surgery</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Studies</topic><topic>Success</topic><topic>Surgical outcomes</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldman, Rachel L.</creatorcontrib><creatorcontrib>Canterberry, Melanie</creatorcontrib><creatorcontrib>Borckardt, Jeffrey J.</creatorcontrib><creatorcontrib>Madan, Alok</creatorcontrib><creatorcontrib>Byrne, T. Karl</creatorcontrib><creatorcontrib>George, Mark S.</creatorcontrib><creatorcontrib>O'Neil, Patrick M.</creatorcontrib><creatorcontrib>Hanlon, Colleen A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldman, Rachel L.</au><au>Canterberry, Melanie</au><au>Borckardt, Jeffrey J.</au><au>Madan, Alok</au><au>Byrne, T. Karl</au><au>George, Mark S.</au><au>O'Neil, Patrick M.</au><au>Hanlon, Colleen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Executive control circuitry differentiates degree of success in weight loss following gastric‐bypass surgery</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2013-11</date><risdate>2013</risdate><volume>21</volume><issue>11</issue><spage>2189</spage><epage>2196</epage><pages>2189-2196</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric‐bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues.
Design and Methods
In this functional MRI study, 31 post‐surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to “crave” or to “resist” craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss.
Results
Overall, instructions to “crave” elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas “resist” elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to “crave.” The more successful participants however had significantly more activity in the DLPFC when instructed to “resist.”
Conclusions
These findings suggest that the ability to mobilize neural circuits involved in executive control post‐gastric‐bypass surgery may be a unique component of successful outcome post‐surgery.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24136926</pmid><doi>10.1002/oby.20575</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2013-11, Vol.21 (11), p.2189-2196 |
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| language | eng |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Addictions Addictive behaviors Adult Aged Behavior Brain research Eating disorders Executive Function - physiology Female Food Gastric Bypass Gastrointestinal surgery Heart surgery Humans Magnetic Resonance Imaging Male Middle Aged Motivation Nerve Net - physiology Neural networks Obesity Obesity, Morbid - diagnosis Obesity, Morbid - physiopathology Obesity, Morbid - psychology Obesity, Morbid - surgery Postoperative Period Prognosis Studies Success Surgical outcomes Treatment Outcome Weight control Weight Loss Young Adult |
| title | Executive control circuitry differentiates degree of success in weight loss following gastric‐bypass surgery |
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