Allosteric regulation of rhomboid intramembrane proteolysis

Proteolysis within the lipid bilayer is poorly understood, in particular the regulation of substrate cleavage. Rhomboids are a family of ubiquitous intramembrane serine proteases that harbour a buried active site and are known to cleave transmembrane substrates with broad specificity. In vitro gel a...

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Veröffentlicht in:	The EMBO journal 2014-09, Vol.33 (17), p.1869-1881
Hauptverfasser:	Arutyunova, Elena, Panwar, Pankaj, Skiba, Pauline M, Gale, Nicola, Mak, Michelle W, Lemieux, M Joanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation allostery Catalysis Cell Membrane - enzymology Cell Membrane - metabolism E coli EMBO20 EMBO31 Energy transfer Escherichia coli - enzymology Escherichia coli - metabolism Fluorescence Resonance Energy Transfer GlpG Haemophilus influenzae - enzymology Haemophilus influenzae - metabolism intramembrane protease Kinetics Lipids Membrane Proteins - metabolism Microbiology Molecular biology Proteases Protein Binding Proteolysis Providencia - enzymology Providencia - metabolism rhomboid protease Serine Proteases - metabolism Substrates
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