Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia

Primary cilia are solitary, microtubule‐based organelles that serve as signaling hubs for the Hedgehog (Hh) pathway, which regulates embryonic development and adult tissue homeostasis. While protein localization studies have suggested that the dynamic trafficking of Hh components at cilia plays an i...

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Veröffentlicht in:	The EMBO journal 2014-09, Vol.33 (17), p.1852-1854
Hauptverfasser:	Pusapati, Ganesh V, Rohatgi, Rajat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cellular biology Cilia - metabolism EMBO05 EMBO37 Embryonic growth stage Have You Seen? Hedgehog Proteins - metabolism Humans Kinesin - metabolism Molecular biology Signal Transduction Transcription factors
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