Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells

Resistance to chemotherapy represents a major obstacle in correcting colorectal carcinomas (CRC). Inspite of recent advances in the treatment of metastatic disease, the prognosis of the patients remains poor. RLX, a vasicinone analogue has been reported to possess potent bronchodilator, anti-asthmat...

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Veröffentlicht in:	BMC cell biology 2014-10, Vol.15 (1), p.36-36, Article 36
Hauptverfasser:	Qazi, Asif Khurshid, Hussain, Aashiq, Aga, Mushtaq A, Ali, Shakir, Taneja, Subhash Chandra, Sharma, Parduman Raj, Saxena, Ajit Kumar, Mondhe, Dilip M, Hamid, Abid
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae - chemistry Alkaloids - chemistry Alkaloids - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Caspase 3 - genetics Caspase 3 - metabolism Cell Movement Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Down-Regulation - drug effects HCT116 Cells Humans Membrane Potential, Mitochondrial NF-kappa B - metabolism Up-Regulation - drug effects
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