Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs
Complex three-dimensional waves of excitation can explain the observed cell movement pattern in Dictyostelium slugs. Here we show that these three-dimensional waves can be produced by a realistic model for the cAMP relay system [Martiel, J.L. and Goldbeter, A. (1987) Biophys J. 52, 807-828]. The con...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1995-05, Vol.92 (10), p.4387-4391 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4391 |
|---|---|
| container_issue | 10 |
| container_start_page | 4387 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 92 |
| creator | Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.) Siegert, F Weijer, C.J |
| description | Complex three-dimensional waves of excitation can explain the observed cell movement pattern in Dictyostelium slugs. Here we show that these three-dimensional waves can be produced by a realistic model for the cAMP relay system [Martiel, J.L. and Goldbeter, A. (1987) Biophys J. 52, 807-828]. The conversion of scroll waves in the prestalk zone of the slug into planar wave fronts in the prespore zone can result from a smaller fraction of relaying cells in the prespore zone. Further, we show that the cAMP concentrations to which cells in a slug are exposed over time display a simple pattern, despite the complex spatial geometry of the waves. This cAMP distribution agrees well with observed patterns of cAMP-regulated cell type-specific gene expression. The core of the spiral, which is a region of low cAMP concentration, might direct expression of stalk-specific genes during culmination |
| doi_str_mv | 10.1073/pnas.92.10.4387 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_41949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2367332</jstor_id><sourcerecordid>2367332</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4547-5125a5f99064c20048833ae1cc722d87307c32548f57ddbe1da965fc5fb2ad373</originalsourceid><addsrcrecordid>eNqFkc2LFDEQxYMo67p6FkQleNBTz-azk4CXZf2EFQV3zyGTpGczpDtj0j3u_vemmXFwPeipKN7vFVX1AHiK0QIjQU83gykLRWqzYFSKe-AYI4Wblil0HxwjREQjGWEPwaNS1gghxSU6AkdCcCpxewzi5XX2vnGh90MJaTARFptTjPCn2foCUwft2Zdv0KYpOuhC9naE1le9T1tfTSM0g4MrP3jobzbZl3kKDAN8F-x4m8roY5h6WOK0Ko_Bg87E4p_s6wm4-vD-8vxTc_H14-fzs4vGMs5EwzHhhndKoZZZghCTklLjsbWCECcFRcJSwpnsuHBu6bEzquWd5d2SGEcFPQFvd3M307L3ztYts4l6k0Nv8q1OJui7yhCu9SptNcOKqWp_vbfn9GPyZdR9KPPNZvBpKloIIhGV7L8gboVo66cr-OovcJ2mXJ9dNEGYiBqKrNDpDqr_LyX77rAwRnoOW89ha0Xmfg67Ol78eeeB36db9Zd7fTb-Vu8MePNPQHdTjKO_GSv5fEeuy5jyASW0FZSSKj_byZ1J2qxyKPrqu6oRKSLpL35e0I4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201275808</pqid></control><display><type>article</type><title>Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.) ; Siegert, F ; Weijer, C.J</creator><creatorcontrib>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.) ; Siegert, F ; Weijer, C.J</creatorcontrib><description>Complex three-dimensional waves of excitation can explain the observed cell movement pattern in Dictyostelium slugs. Here we show that these three-dimensional waves can be produced by a realistic model for the cAMP relay system [Martiel, J.L. and Goldbeter, A. (1987) Biophys J. 52, 807-828]. The conversion of scroll waves in the prestalk zone of the slug into planar wave fronts in the prespore zone can result from a smaller fraction of relaying cells in the prespore zone. Further, we show that the cAMP concentrations to which cells in a slug are exposed over time display a simple pattern, despite the complex spatial geometry of the waves. This cAMP distribution agrees well with observed patterns of cAMP-regulated cell type-specific gene expression. The core of the spiral, which is a region of low cAMP concentration, might direct expression of stalk-specific genes during culmination</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.92.10.4387</identifier><identifier>PMID: 7753816</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>ADENOSINE MONOPHOSPHATE ; Adenosine Triphosphate - metabolism ; ADENOSINMONOFOSFATO ; Aggregation ; Animals ; Cell Membrane - physiology ; Cell motility ; Cell Movement ; Cells ; Cellular biology ; Cyclic AMP - physiology ; Cylinders ; DICTYOSTELIUM ; Dictyostelium - genetics ; Dictyostelium - physiology ; Dictyostelium discoideum ; Dictyostelium mucoroides ; DIFERENCIACION CELULAR ; DIFFERENCIATION CELLULAIRE ; Gene Expression ; Genes ; MECANISME CHIMIOTACTIQUE ; Models, Biological ; Physics ; QUIMIOTACTISMO ; Receptors ; Scrolls ; Slugs ; Time Factors ; Wave fronts ; Wave propagation</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1995-05, Vol.92 (10), p.4387-4391</ispartof><rights>Copyright 1995 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences May 9, 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4547-5125a5f99064c20048833ae1cc722d87307c32548f57ddbe1da965fc5fb2ad373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/92/10.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2367332$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2367332$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7753816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.)</creatorcontrib><creatorcontrib>Siegert, F</creatorcontrib><creatorcontrib>Weijer, C.J</creatorcontrib><title>Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Complex three-dimensional waves of excitation can explain the observed cell movement pattern in Dictyostelium slugs. Here we show that these three-dimensional waves can be produced by a realistic model for the cAMP relay system [Martiel, J.L. and Goldbeter, A. (1987) Biophys J. 52, 807-828]. The conversion of scroll waves in the prestalk zone of the slug into planar wave fronts in the prespore zone can result from a smaller fraction of relaying cells in the prespore zone. Further, we show that the cAMP concentrations to which cells in a slug are exposed over time display a simple pattern, despite the complex spatial geometry of the waves. This cAMP distribution agrees well with observed patterns of cAMP-regulated cell type-specific gene expression. The core of the spiral, which is a region of low cAMP concentration, might direct expression of stalk-specific genes during culmination</description><subject>ADENOSINE MONOPHOSPHATE</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>ADENOSINMONOFOSFATO</subject><subject>Aggregation</subject><subject>Animals</subject><subject>Cell Membrane - physiology</subject><subject>Cell motility</subject><subject>Cell Movement</subject><subject>Cells</subject><subject>Cellular biology</subject><subject>Cyclic AMP - physiology</subject><subject>Cylinders</subject><subject>DICTYOSTELIUM</subject><subject>Dictyostelium - genetics</subject><subject>Dictyostelium - physiology</subject><subject>Dictyostelium discoideum</subject><subject>Dictyostelium mucoroides</subject><subject>DIFERENCIACION CELULAR</subject><subject>DIFFERENCIATION CELLULAIRE</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>MECANISME CHIMIOTACTIQUE</subject><subject>Models, Biological</subject><subject>Physics</subject><subject>QUIMIOTACTISMO</subject><subject>Receptors</subject><subject>Scrolls</subject><subject>Slugs</subject><subject>Time Factors</subject><subject>Wave fronts</subject><subject>Wave propagation</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LFDEQxYMo67p6FkQleNBTz-azk4CXZf2EFQV3zyGTpGczpDtj0j3u_vemmXFwPeipKN7vFVX1AHiK0QIjQU83gykLRWqzYFSKe-AYI4Wblil0HxwjREQjGWEPwaNS1gghxSU6AkdCcCpxewzi5XX2vnGh90MJaTARFptTjPCn2foCUwft2Zdv0KYpOuhC9naE1le9T1tfTSM0g4MrP3jobzbZl3kKDAN8F-x4m8roY5h6WOK0Ko_Bg87E4p_s6wm4-vD-8vxTc_H14-fzs4vGMs5EwzHhhndKoZZZghCTklLjsbWCECcFRcJSwpnsuHBu6bEzquWd5d2SGEcFPQFvd3M307L3ztYts4l6k0Nv8q1OJui7yhCu9SptNcOKqWp_vbfn9GPyZdR9KPPNZvBpKloIIhGV7L8gboVo66cr-OovcJ2mXJ9dNEGYiBqKrNDpDqr_LyX77rAwRnoOW89ha0Xmfg67Ol78eeeB36db9Zd7fTb-Vu8MePNPQHdTjKO_GSv5fEeuy5jyASW0FZSSKj_byZ1J2qxyKPrqu6oRKSLpL35e0I4</recordid><startdate>19950509</startdate><enddate>19950509</enddate><creator>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.)</creator><creator>Siegert, F</creator><creator>Weijer, C.J</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19950509</creationdate><title>Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs</title><author>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.) ; Siegert, F ; Weijer, C.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4547-5125a5f99064c20048833ae1cc722d87307c32548f57ddbe1da965fc5fb2ad373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ADENOSINE MONOPHOSPHATE</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>ADENOSINMONOFOSFATO</topic><topic>Aggregation</topic><topic>Animals</topic><topic>Cell Membrane - physiology</topic><topic>Cell motility</topic><topic>Cell Movement</topic><topic>Cells</topic><topic>Cellular biology</topic><topic>Cyclic AMP - physiology</topic><topic>Cylinders</topic><topic>DICTYOSTELIUM</topic><topic>Dictyostelium - genetics</topic><topic>Dictyostelium - physiology</topic><topic>Dictyostelium discoideum</topic><topic>Dictyostelium mucoroides</topic><topic>DIFERENCIACION CELULAR</topic><topic>DIFFERENCIATION CELLULAIRE</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>MECANISME CHIMIOTACTIQUE</topic><topic>Models, Biological</topic><topic>Physics</topic><topic>QUIMIOTACTISMO</topic><topic>Receptors</topic><topic>Scrolls</topic><topic>Slugs</topic><topic>Time Factors</topic><topic>Wave fronts</topic><topic>Wave propagation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.)</creatorcontrib><creatorcontrib>Siegert, F</creatorcontrib><creatorcontrib>Weijer, C.J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bretschneider, T. (Ludwig-Maximilians-Universitat Munchen, Munich, Germany.)</au><au>Siegert, F</au><au>Weijer, C.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1995-05-09</date><risdate>1995</risdate><volume>92</volume><issue>10</issue><spage>4387</spage><epage>4391</epage><pages>4387-4391</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Complex three-dimensional waves of excitation can explain the observed cell movement pattern in Dictyostelium slugs. Here we show that these three-dimensional waves can be produced by a realistic model for the cAMP relay system [Martiel, J.L. and Goldbeter, A. (1987) Biophys J. 52, 807-828]. The conversion of scroll waves in the prestalk zone of the slug into planar wave fronts in the prespore zone can result from a smaller fraction of relaying cells in the prespore zone. Further, we show that the cAMP concentrations to which cells in a slug are exposed over time display a simple pattern, despite the complex spatial geometry of the waves. This cAMP distribution agrees well with observed patterns of cAMP-regulated cell type-specific gene expression. The core of the spiral, which is a region of low cAMP concentration, might direct expression of stalk-specific genes during culmination</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>7753816</pmid><doi>10.1073/pnas.92.10.4387</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1995-05, Vol.92 (10), p.4387-4391 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_41949 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | ADENOSINE MONOPHOSPHATE Adenosine Triphosphate - metabolism ADENOSINMONOFOSFATO Aggregation Animals Cell Membrane - physiology Cell motility Cell Movement Cells Cellular biology Cyclic AMP - physiology Cylinders DICTYOSTELIUM Dictyostelium - genetics Dictyostelium - physiology Dictyostelium discoideum Dictyostelium mucoroides DIFERENCIACION CELULAR DIFFERENCIATION CELLULAIRE Gene Expression Genes MECANISME CHIMIOTACTIQUE Models, Biological Physics QUIMIOTACTISMO Receptors Scrolls Slugs Time Factors Wave fronts Wave propagation |
| title | Three-dimensional scroll waves of cAMP could direct cell movement and gene expression in Dictyostelium slugs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A11%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three-dimensional%20scroll%20waves%20of%20cAMP%20could%20direct%20cell%20movement%20and%20gene%20expression%20in%20Dictyostelium%20slugs&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Bretschneider,%20T.%20(Ludwig-Maximilians-Universitat%20Munchen,%20Munich,%20Germany.)&rft.date=1995-05-09&rft.volume=92&rft.issue=10&rft.spage=4387&rft.epage=4391&rft.pages=4387-4391&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.92.10.4387&rft_dat=%3Cjstor_pubme%3E2367332%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201275808&rft_id=info:pmid/7753816&rft_jstor_id=2367332&rfr_iscdi=true |