Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)
High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dis...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2014-09, Vol.19 (5), p.e444-e450 |
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| container_title | Medicina oral, patología oral y cirugía bucal |
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| creator | Bachmeier, Evelin Mazzeo, Marcelo-Adrián López, María-Marcela Linares, Jorge-Alberto Jarchum, Gustavo Wietz, Fernando-Martín Finkelberg, Ana-Beatriz |
| description | High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva.
Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used.
85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p |
| doi_str_mv | 10.4317/medoral.19062 |
| format | Article |
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Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used.
85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values.
SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of higher degrees of mucositis.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.19062</identifier><identifier>PMID: 24608218</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Adult ; Aged ; Bone Marrow Transplantation ; Dentistry ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Mucositis - metabolism ; Postoperative Complications - metabolism ; Saliva - chemistry ; Superoxide Dismutase - analysis ; Uric Acid - analysis</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2014-09, Vol.19 (5), p.e444-e450</ispartof><rights>Copyright: © 2014 Medicina Oral S.L. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-fe8ecbe79d0a18f10767cc5d6f2b7f6b43b3680fee5e62ccabd37b936e0cc6f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192566/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192566/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24608218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bachmeier, Evelin</creatorcontrib><creatorcontrib>Mazzeo, Marcelo-Adrián</creatorcontrib><creatorcontrib>López, María-Marcela</creatorcontrib><creatorcontrib>Linares, Jorge-Alberto</creatorcontrib><creatorcontrib>Jarchum, Gustavo</creatorcontrib><creatorcontrib>Wietz, Fernando-Martín</creatorcontrib><creatorcontrib>Finkelberg, Ana-Beatriz</creatorcontrib><title>Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva.
Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used.
85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values.
SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of higher degrees of mucositis.</description><subject>Adult</subject><subject>Aged</subject><subject>Bone Marrow Transplantation</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucositis - metabolism</subject><subject>Postoperative Complications - metabolism</subject><subject>Saliva - chemistry</subject><subject>Superoxide Dismutase - analysis</subject><subject>Uric Acid - analysis</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1PAjEQxRujEUSPXs0e8bDY7kfbvZgo8SuBeOFo0nS7U6xZttjuovz3FkGCp5lJf3nzOg-hS4JHWUrYzQIq62Q9IgWmyRHqE1rwmBYZPT7oe-jM-w-MU0YYPUW9JKOYJ4T30du0U9ab1vhINlXkZW1W0q3D0Br7bapQfWSaaClbA5u-aypwc2uaeVTaBqKFdM5-Ra2TjV_WAQ-gbaLh_XR2fY5OtKw9XOzqAM0eH2bj53jy-vQyvpvEKstZG2vgoEpgRYUl4ZpgRplSeUV1UjJNyywtU8qxBsiBJkrJskpZWaQUsFJUpwN0u5VddmU4hwo-w0XE0plgbi2sNOL_S2PexdyuREaKJKc0CAx3As5-duBbsTBeQR2-A7bzguQ5zxOeJRs03qLKWe8d6P0agsUmELELRPwGEvirQ297-i-B9AcXUIx7</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Bachmeier, Evelin</creator><creator>Mazzeo, Marcelo-Adrián</creator><creator>López, María-Marcela</creator><creator>Linares, Jorge-Alberto</creator><creator>Jarchum, Gustavo</creator><creator>Wietz, Fernando-Martín</creator><creator>Finkelberg, Ana-Beatriz</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)</title><author>Bachmeier, Evelin ; Mazzeo, Marcelo-Adrián ; López, María-Marcela ; Linares, Jorge-Alberto ; Jarchum, Gustavo ; Wietz, Fernando-Martín ; Finkelberg, Ana-Beatriz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-fe8ecbe79d0a18f10767cc5d6f2b7f6b43b3680fee5e62ccabd37b936e0cc6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bone Marrow Transplantation</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucositis - metabolism</topic><topic>Postoperative Complications - metabolism</topic><topic>Saliva - chemistry</topic><topic>Superoxide Dismutase - analysis</topic><topic>Uric Acid - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bachmeier, Evelin</creatorcontrib><creatorcontrib>Mazzeo, Marcelo-Adrián</creatorcontrib><creatorcontrib>López, María-Marcela</creatorcontrib><creatorcontrib>Linares, Jorge-Alberto</creatorcontrib><creatorcontrib>Jarchum, Gustavo</creatorcontrib><creatorcontrib>Wietz, Fernando-Martín</creatorcontrib><creatorcontrib>Finkelberg, Ana-Beatriz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bachmeier, Evelin</au><au>Mazzeo, Marcelo-Adrián</au><au>López, María-Marcela</au><au>Linares, Jorge-Alberto</au><au>Jarchum, Gustavo</au><au>Wietz, Fernando-Martín</au><au>Finkelberg, Ana-Beatriz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>19</volume><issue>5</issue><spage>e444</spage><epage>e450</epage><pages>e444-e450</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva.
Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used.
85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p<0.01) compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in stage M compared with stage I, and in stage F it recovered the initial values.
SOD increase in stage M coincided with the appearance of mucositis, which could be interpreted as a defensive mechanism of saliva against oxidative stress produced by chemotherapy. UA decrease in stage M would favour the development of higher degrees of mucositis.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>24608218</pmid><doi>10.4317/medoral.19062</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Bone Marrow Transplantation Dentistry Female Humans Longitudinal Studies Male Middle Aged Mucositis - metabolism Postoperative Complications - metabolism Saliva - chemistry Superoxide Dismutase - analysis Uric Acid - analysis |
| title | Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT) |
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