Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.
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| Veröffentlicht in: | The New England journal of medicine 2014-09, Vol.371 (11), p.1005-1015 |
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| container_title | The New England journal of medicine |
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| creator | Roberts, Kathryn G Li, Yongjin Payne-Turner, Debbie Harvey, Richard C Yang, Yung-Li Pei, Deqing McCastlain, Kelly Ding, Li Lu, Charles Song, Guangchun Ma, Jing Becksfort, Jared Rusch, Michael Chen, Shann-Ching Easton, John Cheng, Jinjun Boggs, Kristy Santiago-Morales, Natalia Iacobucci, Ilaria Fulton, Robert S Wen, Ji Valentine, Marcus Cheng, Cheng Paugh, Steven W Devidas, Meenakshi Chen, I-Ming Reshmi, Shalini Smith, Amy Hedlund, Erin Gupta, Pankaj Nagahawatte, Panduka Wu, Gang Chen, Xiang Yergeau, Donald Vadodaria, Bhavin Mulder, Heather Winick, Naomi J Larsen, Eric C Carroll, William L Heerema, Nyla A Carroll, Andrew J Grayson, Guy Tasian, Sarah K Moore, Andrew S Keller, Frank Frei-Jones, Melissa Whitlock, James A Raetz, Elizabeth A White, Deborah L Hughes, Timothy P Guidry Auvil, Jaime M Smith, Malcolm A Marcucci, Guido Bloomfield, Clara D Mrózek, Krzysztof Kohlschmidt, Jessica Stock, Wendy Kornblau, Steven M Konopleva, Marina Paietta, Elisabeth Pui, Ching-Hon Jeha, Sima Relling, Mary V Evans, William E Gerhard, Daniela S Gastier-Foster, Julie M Mardis, Elaine Wilson, Richard K Loh, Mignon L Downing, James R Hunger, Stephen P Willman, Cheryl L Zhang, Jinghui Mullighan, Charles G |
| description | About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents. |
| doi_str_mv | 10.1056/NEJMoa1403088 |
| format | Article |
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In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1403088</identifier><identifier>PMID: 25207766</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Adolescents ; Adult ; Age ; Animals ; Biological and medical sciences ; Cell activation ; Cell proliferation ; Child ; Child, Preschool ; Children ; Clinical trials ; DNA, Neoplasm - analysis ; Female ; Gene expression ; General aspects ; Genes ; Genome, Human ; Genomes ; Genomic analysis ; Hematologic and hematopoietic diseases ; Heterografts ; Humans ; Infant ; Interleukin 7 receptors ; Janus kinase 2 ; Kinases ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic leukemia ; Lymphocytes B ; Male ; Medical sciences ; Mice ; Oligonucleotide Array Sequence Analysis ; Oncology ; Philadelphia Chromosome ; Polymorphism, Single Nucleotide ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Protein Kinase Inhibitors - therapeutic use ; Protein-tyrosine kinase ; Protein-Tyrosine Kinases - antagonists & inhibitors ; Receptors, Cytokine - genetics ; Receptors, Cytokine - metabolism ; Signal Transduction - genetics ; Stat5 protein ; Survival Analysis ; Teenagers ; Thymic stromal lymphopoietin ; Tyk2 protein ; Xenografts ; Young Adult ; Young adults</subject><ispartof>The New England journal of medicine, 2014-09, Vol.371 (11), p.1005-1015</ispartof><rights>Copyright © 2014 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Massachusetts Medical Society. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-a07c4aaa574c7fca72822bc2fb80277f40755d545f597691efab996a5e79820e3</citedby><cites>FETCH-LOGICAL-c519t-a07c4aaa574c7fca72822bc2fb80277f40755d545f597691efab996a5e79820e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1403088$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1403088$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29054076$$DView 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Kristy</creatorcontrib><creatorcontrib>Santiago-Morales, Natalia</creatorcontrib><creatorcontrib>Iacobucci, Ilaria</creatorcontrib><creatorcontrib>Fulton, Robert S</creatorcontrib><creatorcontrib>Wen, Ji</creatorcontrib><creatorcontrib>Valentine, Marcus</creatorcontrib><creatorcontrib>Cheng, Cheng</creatorcontrib><creatorcontrib>Paugh, Steven W</creatorcontrib><creatorcontrib>Devidas, Meenakshi</creatorcontrib><creatorcontrib>Chen, I-Ming</creatorcontrib><creatorcontrib>Reshmi, Shalini</creatorcontrib><creatorcontrib>Smith, Amy</creatorcontrib><creatorcontrib>Hedlund, Erin</creatorcontrib><creatorcontrib>Gupta, Pankaj</creatorcontrib><creatorcontrib>Nagahawatte, Panduka</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Chen, Xiang</creatorcontrib><creatorcontrib>Yergeau, Donald</creatorcontrib><creatorcontrib>Vadodaria, Bhavin</creatorcontrib><creatorcontrib>Mulder, Heather</creatorcontrib><creatorcontrib>Winick, Naomi J</creatorcontrib><creatorcontrib>Larsen, Eric C</creatorcontrib><creatorcontrib>Carroll, William L</creatorcontrib><creatorcontrib>Heerema, Nyla A</creatorcontrib><creatorcontrib>Carroll, Andrew J</creatorcontrib><creatorcontrib>Grayson, Guy</creatorcontrib><creatorcontrib>Tasian, Sarah K</creatorcontrib><creatorcontrib>Moore, Andrew S</creatorcontrib><creatorcontrib>Keller, Frank</creatorcontrib><creatorcontrib>Frei-Jones, Melissa</creatorcontrib><creatorcontrib>Whitlock, James A</creatorcontrib><creatorcontrib>Raetz, Elizabeth A</creatorcontrib><creatorcontrib>White, Deborah L</creatorcontrib><creatorcontrib>Hughes, Timothy P</creatorcontrib><creatorcontrib>Guidry Auvil, Jaime M</creatorcontrib><creatorcontrib>Smith, Malcolm A</creatorcontrib><creatorcontrib>Marcucci, Guido</creatorcontrib><creatorcontrib>Bloomfield, Clara D</creatorcontrib><creatorcontrib>Mrózek, Krzysztof</creatorcontrib><creatorcontrib>Kohlschmidt, Jessica</creatorcontrib><creatorcontrib>Stock, Wendy</creatorcontrib><creatorcontrib>Kornblau, Steven M</creatorcontrib><creatorcontrib>Konopleva, Marina</creatorcontrib><creatorcontrib>Paietta, Elisabeth</creatorcontrib><creatorcontrib>Pui, Ching-Hon</creatorcontrib><creatorcontrib>Jeha, Sima</creatorcontrib><creatorcontrib>Relling, Mary V</creatorcontrib><creatorcontrib>Evans, William E</creatorcontrib><creatorcontrib>Gerhard, Daniela S</creatorcontrib><creatorcontrib>Gastier-Foster, Julie M</creatorcontrib><creatorcontrib>Mardis, Elaine</creatorcontrib><creatorcontrib>Wilson, Richard K</creatorcontrib><creatorcontrib>Loh, Mignon L</creatorcontrib><creatorcontrib>Downing, James R</creatorcontrib><creatorcontrib>Hunger, Stephen P</creatorcontrib><creatorcontrib>Willman, Cheryl L</creatorcontrib><creatorcontrib>Zhang, Jinghui</creatorcontrib><creatorcontrib>Mullighan, Charles G</creatorcontrib><title>Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Age</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell activation</subject><subject>Cell proliferation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clinical trials</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Gene expression</subject><subject>General aspects</subject><subject>Genes</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomic analysis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Heterografts</subject><subject>Humans</subject><subject>Infant</subject><subject>Interleukin 7 receptors</subject><subject>Janus kinase 2</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology</subject><subject>Philadelphia Chromosome</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Protein Kinase Inhibitors - therapeutic use</subject><subject>Protein-tyrosine kinase</subject><subject>Protein-Tyrosine Kinases - antagonists & inhibitors</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Signal Transduction - genetics</subject><subject>Stat5 protein</subject><subject>Survival Analysis</subject><subject>Teenagers</subject><subject>Thymic stromal lymphopoietin</subject><subject>Tyk2 protein</subject><subject>Xenografts</subject><subject>Young Adult</subject><subject>Young 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Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia</title><author>Roberts, Kathryn G ; Li, Yongjin ; Payne-Turner, Debbie ; Harvey, Richard C ; Yang, Yung-Li ; Pei, Deqing ; McCastlain, Kelly ; Ding, Li ; Lu, Charles ; Song, Guangchun ; Ma, Jing ; Becksfort, Jared ; Rusch, Michael ; Chen, Shann-Ching ; Easton, John ; Cheng, Jinjun ; Boggs, Kristy ; Santiago-Morales, Natalia ; Iacobucci, Ilaria ; Fulton, Robert S ; Wen, Ji ; Valentine, Marcus ; Cheng, Cheng ; Paugh, Steven W ; Devidas, Meenakshi ; Chen, I-Ming ; Reshmi, Shalini ; Smith, Amy ; Hedlund, Erin ; Gupta, Pankaj ; Nagahawatte, Panduka ; Wu, Gang ; Chen, Xiang ; Yergeau, Donald ; Vadodaria, Bhavin ; Mulder, Heather ; Winick, Naomi J ; Larsen, Eric C ; Carroll, William L ; Heerema, Nyla A ; Carroll, Andrew J ; Grayson, Guy ; Tasian, Sarah K ; Moore, Andrew S ; Keller, Frank ; Frei-Jones, Melissa ; Whitlock, James A ; Raetz, Elizabeth A ; White, Deborah L ; Hughes, Timothy P ; Guidry Auvil, Jaime M ; Smith, Malcolm A ; Marcucci, Guido ; Bloomfield, Clara D ; Mrózek, Krzysztof ; Kohlschmidt, Jessica ; Stock, Wendy ; Kornblau, Steven M ; Konopleva, Marina ; Paietta, Elisabeth ; Pui, Ching-Hon ; Jeha, Sima ; Relling, Mary V ; Evans, William E ; Gerhard, Daniela S ; Gastier-Foster, Julie M ; Mardis, Elaine ; Wilson, Richard K ; Loh, Mignon L ; Downing, James R ; Hunger, Stephen P ; Willman, Cheryl L ; Zhang, Jinghui ; Mullighan, Charles G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-a07c4aaa574c7fca72822bc2fb80277f40755d545f597691efab996a5e79820e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Age</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell activation</topic><topic>Cell proliferation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clinical trials</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Gene expression</topic><topic>General aspects</topic><topic>Genes</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomic analysis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Heterografts</topic><topic>Humans</topic><topic>Infant</topic><topic>Interleukin 7 receptors</topic><topic>Janus kinase 2</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncology</topic><topic>Philadelphia Chromosome</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Protein Kinase Inhibitors - therapeutic use</topic><topic>Protein-tyrosine kinase</topic><topic>Protein-Tyrosine Kinases - antagonists & inhibitors</topic><topic>Receptors, Cytokine - genetics</topic><topic>Receptors, Cytokine - metabolism</topic><topic>Signal Transduction - genetics</topic><topic>Stat5 protein</topic><topic>Survival Analysis</topic><topic>Teenagers</topic><topic>Thymic stromal lymphopoietin</topic><topic>Tyk2 protein</topic><topic>Xenografts</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Kathryn G</creatorcontrib><creatorcontrib>Li, Yongjin</creatorcontrib><creatorcontrib>Payne-Turner, Debbie</creatorcontrib><creatorcontrib>Harvey, Richard C</creatorcontrib><creatorcontrib>Yang, Yung-Li</creatorcontrib><creatorcontrib>Pei, Deqing</creatorcontrib><creatorcontrib>McCastlain, Kelly</creatorcontrib><creatorcontrib>Ding, Li</creatorcontrib><creatorcontrib>Lu, Charles</creatorcontrib><creatorcontrib>Song, Guangchun</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Becksfort, Jared</creatorcontrib><creatorcontrib>Rusch, Michael</creatorcontrib><creatorcontrib>Chen, Shann-Ching</creatorcontrib><creatorcontrib>Easton, John</creatorcontrib><creatorcontrib>Cheng, Jinjun</creatorcontrib><creatorcontrib>Boggs, Kristy</creatorcontrib><creatorcontrib>Santiago-Morales, Natalia</creatorcontrib><creatorcontrib>Iacobucci, Ilaria</creatorcontrib><creatorcontrib>Fulton, Robert S</creatorcontrib><creatorcontrib>Wen, Ji</creatorcontrib><creatorcontrib>Valentine, Marcus</creatorcontrib><creatorcontrib>Cheng, Cheng</creatorcontrib><creatorcontrib>Paugh, Steven W</creatorcontrib><creatorcontrib>Devidas, Meenakshi</creatorcontrib><creatorcontrib>Chen, I-Ming</creatorcontrib><creatorcontrib>Reshmi, Shalini</creatorcontrib><creatorcontrib>Smith, Amy</creatorcontrib><creatorcontrib>Hedlund, Erin</creatorcontrib><creatorcontrib>Gupta, Pankaj</creatorcontrib><creatorcontrib>Nagahawatte, Panduka</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Chen, Xiang</creatorcontrib><creatorcontrib>Yergeau, Donald</creatorcontrib><creatorcontrib>Vadodaria, Bhavin</creatorcontrib><creatorcontrib>Mulder, Heather</creatorcontrib><creatorcontrib>Winick, Naomi J</creatorcontrib><creatorcontrib>Larsen, Eric C</creatorcontrib><creatorcontrib>Carroll, William L</creatorcontrib><creatorcontrib>Heerema, Nyla A</creatorcontrib><creatorcontrib>Carroll, Andrew J</creatorcontrib><creatorcontrib>Grayson, Guy</creatorcontrib><creatorcontrib>Tasian, Sarah K</creatorcontrib><creatorcontrib>Moore, Andrew S</creatorcontrib><creatorcontrib>Keller, Frank</creatorcontrib><creatorcontrib>Frei-Jones, Melissa</creatorcontrib><creatorcontrib>Whitlock, James A</creatorcontrib><creatorcontrib>Raetz, Elizabeth A</creatorcontrib><creatorcontrib>White, Deborah L</creatorcontrib><creatorcontrib>Hughes, Timothy P</creatorcontrib><creatorcontrib>Guidry Auvil, Jaime M</creatorcontrib><creatorcontrib>Smith, Malcolm A</creatorcontrib><creatorcontrib>Marcucci, Guido</creatorcontrib><creatorcontrib>Bloomfield, Clara D</creatorcontrib><creatorcontrib>Mrózek, Krzysztof</creatorcontrib><creatorcontrib>Kohlschmidt, Jessica</creatorcontrib><creatorcontrib>Stock, Wendy</creatorcontrib><creatorcontrib>Kornblau, Steven M</creatorcontrib><creatorcontrib>Konopleva, Marina</creatorcontrib><creatorcontrib>Paietta, Elisabeth</creatorcontrib><creatorcontrib>Pui, Ching-Hon</creatorcontrib><creatorcontrib>Jeha, Sima</creatorcontrib><creatorcontrib>Relling, Mary V</creatorcontrib><creatorcontrib>Evans, William E</creatorcontrib><creatorcontrib>Gerhard, Daniela S</creatorcontrib><creatorcontrib>Gastier-Foster, Julie M</creatorcontrib><creatorcontrib>Mardis, Elaine</creatorcontrib><creatorcontrib>Wilson, Richard K</creatorcontrib><creatorcontrib>Loh, Mignon L</creatorcontrib><creatorcontrib>Downing, James R</creatorcontrib><creatorcontrib>Hunger, Stephen P</creatorcontrib><creatorcontrib>Willman, Cheryl L</creatorcontrib><creatorcontrib>Zhang, Jinghui</creatorcontrib><creatorcontrib>Mullighan, Charles G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural 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Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Kathryn G</au><au>Li, Yongjin</au><au>Payne-Turner, Debbie</au><au>Harvey, Richard C</au><au>Yang, Yung-Li</au><au>Pei, Deqing</au><au>McCastlain, Kelly</au><au>Ding, Li</au><au>Lu, Charles</au><au>Song, Guangchun</au><au>Ma, Jing</au><au>Becksfort, Jared</au><au>Rusch, Michael</au><au>Chen, Shann-Ching</au><au>Easton, John</au><au>Cheng, Jinjun</au><au>Boggs, Kristy</au><au>Santiago-Morales, Natalia</au><au>Iacobucci, Ilaria</au><au>Fulton, Robert S</au><au>Wen, Ji</au><au>Valentine, Marcus</au><au>Cheng, Cheng</au><au>Paugh, Steven W</au><au>Devidas, Meenakshi</au><au>Chen, I-Ming</au><au>Reshmi, Shalini</au><au>Smith, Amy</au><au>Hedlund, Erin</au><au>Gupta, Pankaj</au><au>Nagahawatte, Panduka</au><au>Wu, Gang</au><au>Chen, Xiang</au><au>Yergeau, Donald</au><au>Vadodaria, Bhavin</au><au>Mulder, Heather</au><au>Winick, Naomi J</au><au>Larsen, Eric C</au><au>Carroll, William L</au><au>Heerema, Nyla A</au><au>Carroll, Andrew J</au><au>Grayson, Guy</au><au>Tasian, Sarah K</au><au>Moore, Andrew S</au><au>Keller, Frank</au><au>Frei-Jones, Melissa</au><au>Whitlock, James A</au><au>Raetz, Elizabeth A</au><au>White, Deborah L</au><au>Hughes, Timothy P</au><au>Guidry Auvil, Jaime M</au><au>Smith, Malcolm A</au><au>Marcucci, Guido</au><au>Bloomfield, Clara D</au><au>Mrózek, Krzysztof</au><au>Kohlschmidt, Jessica</au><au>Stock, Wendy</au><au>Kornblau, Steven M</au><au>Konopleva, Marina</au><au>Paietta, Elisabeth</au><au>Pui, Ching-Hon</au><au>Jeha, Sima</au><au>Relling, Mary V</au><au>Evans, William E</au><au>Gerhard, Daniela S</au><au>Gastier-Foster, Julie M</au><au>Mardis, Elaine</au><au>Wilson, Richard K</au><au>Loh, Mignon L</au><au>Downing, James R</au><au>Hunger, Stephen P</au><au>Willman, Cheryl L</au><au>Zhang, Jinghui</au><au>Mullighan, Charles G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2014-09-11</date><risdate>2014</risdate><volume>371</volume><issue>11</issue><spage>1005</spage><epage>1015</epage><pages>1005-1015</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>25207766</pmid><doi>10.1056/NEJMoa1403088</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2014-09, Vol.371 (11), p.1005-1015 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4191900 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Acute lymphoblastic leukemia Adolescent Adolescents Adult Age Animals Biological and medical sciences Cell activation Cell proliferation Child Child, Preschool Children Clinical trials DNA, Neoplasm - analysis Female Gene expression General aspects Genes Genome, Human Genomes Genomic analysis Hematologic and hematopoietic diseases Heterografts Humans Infant Interleukin 7 receptors Janus kinase 2 Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical sciences Mice Oligonucleotide Array Sequence Analysis Oncology Philadelphia Chromosome Polymorphism, Single Nucleotide Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Signal Transduction - genetics Stat5 protein Survival Analysis Teenagers Thymic stromal lymphopoietin Tyk2 protein Xenografts Young Adult Young adults |
| title | Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia |
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