Design and characterization of structured protein linkers with differing flexibilities

Engineered fusion proteins containing two or more functional polypeptides joined by a peptide or protein linker are important for many fields of biological research. The separation distance between functional units can impact epitope access and the ability to bind with avidity; thus the availability...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2014-10, Vol.27 (10), p.325-330
Hauptverfasser:	Klein, Joshua S., Jiang, Siduo, Galimidi, Rachel P., Keeffe, Jennifer R., Bjorkman, Pamela J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chromatography, Gel Creativity Engenders Next-Generation Antibody Engineering Hydrodynamics Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulin G - metabolism Molecular Sequence Data Pliability Protein Conformation Protein Engineering - methods Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism
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