Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA

Dengue virus nonstructural protein 3 (NS3) is a multifunctional protein formed by a superfamily-2 RNA helicase linked to a protease domain. In this work, we report results from in vitro experiments designed to determine the oligomeric state of dengue virus NS3 helicase (NS3h) and to characterize fun...

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Veröffentlicht in:	Nucleic acids research 2014-10, Vol.42 (18), p.11668-11686
Hauptverfasser:	Gebhard, Leopoldo G, Incicco, J Jeremías, Smal, Clara, Gallo, Mariana, Gamarnik, Andrea V, Kaufman, Sergio B
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Dengue Virus - enzymology Nucleic Acid Enzymes Poly A - metabolism Protein Binding Protein Multimerization RNA - chemistry RNA - metabolism RNA Helicases - chemistry RNA Helicases - metabolism Serine Endopeptidases - chemistry Serine Endopeptidases - metabolism Thermodynamics Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism
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