Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual impairment in several common ocular diseases. The angiopoietin/TIE2 (ANG/TIE2) pathway maintains vascular integrity, and negative regulators of this pathway are potential therapeutic targets for these diseases. H...

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Veröffentlicht in:	The Journal of clinical investigation 2014-10, Vol.124 (10), p.4564-4576
Hauptverfasser:	Shen, Jikui, Frye, Maike, Lee, Bonnie L, Reinardy, Jessica L, McClung, Joseph M, Ding, Kun, Kojima, Masashi, Xia, Huiming, Seidel, Christopher, Lima e Silva, Raquel, Dong, Aling, Hackett, Sean F, Wang, Jiangxia, Howard, Brian W, Vestweber, Dietmar, Kontos, Christopher D, Peters, Kevin G, Campochiaro, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aniline Compounds - pharmacology Animals Biomedical research Blood circulation disorders Care and treatment Catalysis Cell Hypoxia Choroid - blood supply Diabetic retinopathy Experiments Eye - blood supply Genetic aspects Human Umbilical Vein Endothelial Cells Humans Hypoxia Laboratory animals Macular Degeneration Mice Mice, Transgenic Neovascularization Oxygen - metabolism Phosphatase Phosphatases Phosphorylation Properties Proteins R&D Receptor, TIE-2 - metabolism Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism Research & development Retinal Vessels - pathology Signal Transduction Sulfonic Acids - pharmacology Transgenic animals Vascular Endothelial Growth Factor A - metabolism
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