TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal...

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Veröffentlicht in:	The Journal of clinical investigation 2014-10, Vol.124 (10), p.4375-4386
Hauptverfasser:	McCarron, Mark J, Marie, Julien C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autoimmunity - immunology B-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology Cell Differentiation Genetic aspects Hyaluronan Receptors - metabolism Immune response Immune Tolerance Immunity, Humoral Interleukin-2 Receptor beta Subunit - metabolism Lymphocyte Activation - immunology Mice Mice, Knockout Properties Proto-Oncogene Proteins c-bcl-2 - metabolism Regulation Signal Transduction T cells T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Regulatory - immunology Thymus Gland - metabolism Transforming Growth Factor beta1 - metabolism Transforming growth factors
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