Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity

In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously w...

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Veröffentlicht in:	Neural regeneration research 2012-12, Vol.7 (35), p.2793-2800
Hauptverfasser:	Wang, Aimei, Hou, Ning, Bao, Dongyan, Liu, Shuangyue, Xu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antioxidants Apoptosis Autonomic Nerve Damage and Neural Regeneration c-Jun Experiments Hair Hearing loss Kinases Laboratory animals Lipid peroxidation Lipids Noise Oxidative stress p38丝裂原活化蛋白激酶 Rodents Signal transduction Studies α-硫辛酸免疫组化染色卡那霉素听性脑干反应毒性机制衰减
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