Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers
Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated wit...
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| Veröffentlicht in: | BMC genomics 2014-10, Vol.15 (1), p.833-833, Article 833 |
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| creator | Sánchez-Molano, Enrique Woolliams, John A Pong-Wong, Ricardo Clements, Dylan N Blott, Sarah C Wiener, Pamela |
| description | Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).
Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease. |
| doi_str_mv | 10.1186/1471-2164-15-833 |
| format | Article |
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Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.</description><identifier>ISSN: 1471-2164</identifier><identifier>EISSN: 1471-2164</identifier><identifier>DOI: 10.1186/1471-2164-15-833</identifier><identifier>PMID: 25270232</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Animals ; Chromosome Mapping ; Chromosomes ; Chromosomes, Mammalian - genetics ; Dog shows ; Dogs ; Genes ; Genetic aspects ; Genomes ; Genomics ; Hip Dysplasia, Canine - genetics ; Osteoarthritis ; Phenotype ; Physiological aspects ; Polymorphism, Single Nucleotide ; Quantitative genetics ; Quantitative Trait Loci - genetics</subject><ispartof>BMC genomics, 2014-10, Vol.15 (1), p.833-833, Article 833</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Sánchez-Molano et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Sánchez-Molano et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b618t-a6d9027004d4f9aed1828a533b562d986e4e43e8095142a0840b129e764a74c13</citedby><cites>FETCH-LOGICAL-b618t-a6d9027004d4f9aed1828a533b562d986e4e43e8095142a0840b129e764a74c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190382/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190382/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25270232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez-Molano, Enrique</creatorcontrib><creatorcontrib>Woolliams, John A</creatorcontrib><creatorcontrib>Pong-Wong, Ricardo</creatorcontrib><creatorcontrib>Clements, Dylan N</creatorcontrib><creatorcontrib>Blott, Sarah C</creatorcontrib><creatorcontrib>Wiener, Pamela</creatorcontrib><title>Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers</title><title>BMC genomics</title><addtitle>BMC Genomics</addtitle><description>Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).
Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.</description><subject>Analysis</subject><subject>Animals</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Dog shows</subject><subject>Dogs</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hip Dysplasia, Canine - genetics</subject><subject>Osteoarthritis</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative genetics</subject><subject>Quantitative Trait Loci - genetics</subject><issn>1471-2164</issn><issn>1471-2164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUk1v1DAUjBCIlsKdE7LEpRxS_B3nglSt-KhYCVHo2XKSl62rxA62s6L_Hkdbli4qEvLB1nsz49G8VxQvCT4jRMm3hFekpETykohSMfaoON6XHt97HxXPYrzBmFSKiqfFERW0wpTR48J-nY1LNplkt4BSMDahwbcWjWaarNug3gfUGmcdoGs7oe42ToOJ1iDjOmRTRAEGk6DbcSOyDl19RmvTBNNl6iWkYGELIT4vnvRmiPDi7j4prj68_776VK6_fLxYna_LRhKVSiO7Gmd3mHe8rw10RFFlBGONkLSrlQQOnIHCtSCcGqw4bgitoZLcVLwl7KR4t9Od5maErgWXnQ16CnY04VZ7Y_Vhx9lrvfFbzUmNmaJZYLUTaKz_h8Bhp_WjXqLWS9SaCJ0nkVVO72wE_2OGmPRoYwvDYBz4OWoiCZEMK6X-A4prgokUi-rrv6A3fg4u55n_VRJzWVP1B7UxA2jrep99touoPhesFlLUVZ1RZw-g8ulgtK130NtcPyC8OSBkTIKfaWPmGPXFt8tDLN5h2-BjDNDv8yNYL7v7UGKv7g9uT_i9rOwXrxznGA</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Sánchez-Molano, Enrique</creator><creator>Woolliams, John A</creator><creator>Pong-Wong, Ricardo</creator><creator>Clements, Dylan N</creator><creator>Blott, Sarah C</creator><creator>Wiener, Pamela</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers</title><author>Sánchez-Molano, Enrique ; Woolliams, John A ; Pong-Wong, Ricardo ; Clements, Dylan N ; Blott, Sarah C ; Wiener, Pamela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b618t-a6d9027004d4f9aed1828a533b562d986e4e43e8095142a0840b129e764a74c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Chromosomes, Mammalian - genetics</topic><topic>Dog shows</topic><topic>Dogs</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Hip Dysplasia, Canine - genetics</topic><topic>Osteoarthritis</topic><topic>Phenotype</topic><topic>Physiological aspects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative genetics</topic><topic>Quantitative Trait Loci - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez-Molano, Enrique</creatorcontrib><creatorcontrib>Woolliams, John A</creatorcontrib><creatorcontrib>Pong-Wong, Ricardo</creatorcontrib><creatorcontrib>Clements, Dylan N</creatorcontrib><creatorcontrib>Blott, Sarah C</creatorcontrib><creatorcontrib>Wiener, Pamela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez-Molano, Enrique</au><au>Woolliams, John A</au><au>Pong-Wong, Ricardo</au><au>Clements, Dylan N</au><au>Blott, Sarah C</au><au>Wiener, Pamela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers</atitle><jtitle>BMC genomics</jtitle><addtitle>BMC Genomics</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>15</volume><issue>1</issue><spage>833</spage><epage>833</epage><pages>833-833</pages><artnum>833</artnum><issn>1471-2164</issn><eissn>1471-2164</eissn><abstract>Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).
Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25270232</pmid><doi>10.1186/1471-2164-15-833</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Chromosome Mapping Chromosomes Chromosomes, Mammalian - genetics Dog shows Dogs Genes Genetic aspects Genomes Genomics Hip Dysplasia, Canine - genetics Osteoarthritis Phenotype Physiological aspects Polymorphism, Single Nucleotide Quantitative genetics Quantitative Trait Loci - genetics |
| title | Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers |
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