Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum

The Pax6 transcription factor is expressed in cerebellar granule cells and when mutated, as in the Sey/Sey mouse, produces granule cells with disturbed survival and migration and with defects in neurite extension. The impact of Pax6 on other genes in the context of cerebellar development has not bee...

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Veröffentlicht in:	The European journal of neuroscience 2012-10, Vol.36 (7), p.2888-2898
Hauptverfasser:	Ha, Thomas J., Swanson, Douglas J., Kirova, Roumyana, Yeung, Joanna, Choi, Kunho, Tong, Yiai, Chesler, Elissa J., Goldowitz, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell migration Cell survival Cerebellum Cerebellum - embryology Cerebellum - metabolism Comparative Genomic Hybridization Data processing Development DNA microarrays Embryos Eye Proteins - genetics Eye Proteins - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental granule cell Granule cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Mice, Knockout Nervous system Oligonucleotide Array Sequence Analysis Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax6 protein PAX6 Transcription Factor Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - metabolism Sey mutant Statistical analysis transcription factor Transcription factors Transcriptome - genetics transcriptome profiling
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