Chloroquine has a cytotoxic effect on Acanthamoeba encystation through modulation of autophagy

Encystation of Acanthamoeba castellanii is associated with resistance to chemotherapeutic agents. Blocking the encystation process could potentiate the efficacy of chemotherapeutic agents and biocides. During encystation, autophagy is highly stimulated and required for proper encystation of Acantham...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-10, Vol.58 (10), p.6235-6241
Hauptverfasser:	Jha, Bijay Kumar, Jung, Hui-Jung, Seo, Incheol, Kim, Hyun Ah, Suh, Seong-Il, Suh, Min-Ho, Baek, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthamoeba Acanthamoeba - drug effects Acanthamoeba castellanii Autophagy Autophagy - drug effects Chloroquine Chloroquine - pharmacology Disinfectants Disinfectants - pharmacology Susceptibility
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