miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by megakaryocyte (MK) hyperplasia, bone marrow fibrosis, and abnormal stem cell trafficking. PMF may be associated with somatic mutations in JAK2, MPL, or CALR. Previous studies have shown that abnormal MKs play a central rol...

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Veröffentlicht in:	Blood 2014-09, Vol.124 (13), p.e21-e32
Hauptverfasser:	Norfo, Ruggiero, Zini, Roberta, Pennucci, Valentina, Bianchi, Elisa, Salati, Simona, Guglielmelli, Paola, Bogani, Costanza, Fanelli, Tiziana, Mannarelli, Carmela, Rosti, Vittorio, Pietra, Daniela, Salmoiraghi, Silvia, Bisognin, Andrea, Ruberti, Samantha, Rontauroli, Sebastiano, Sacchi, Giorgia, Prudente, Zelia, Barosi, Giovanni, Cazzola, Mario, Rambaldi, Alessandro, Bortoluzzi, Stefania, Ferrari, Sergio, Tagliafico, Enrico, Vannucchi, Alessandro M., Manfredini, Rossella
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - metabolism Cell Differentiation - genetics Cell Lineage - genetics Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Gene Silencing Granulocytes - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Megakaryocytes - cytology Megakaryocytes - metabolism MicroRNAs - genetics Myeloid Neoplasia Polycomb Repressive Complex 2 - genetics Primary Myelofibrosis - genetics Reproducibility of Results RNA Interference RNA, Messenger - genetics Thrombopoiesis - genetics
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