Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010
Background Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America. Objective Provide epi...
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| Veröffentlicht in: | Influenza and other respiratory viruses 2014-03, Vol.8 (2), p.217-227 |
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| creator | Villaran, Manuel V. García, Josefina Gomez, Jorge Arango, Ana E. Gonzales, Marina Chicaiza, Wilson Alemán, Washington Lorenzana de Rivera, Ivette Sanchez, Felix Aguayo, Nicolas Kochel, Tadeusz J. Halsey, Eric S. |
| description | Background
Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America.
Objective
Provide epidemiologic and phylogenetic information about HPIVs that circulated in Latin America between 2006 and 2010 to better characterize the extent and variability of this respiratory virus in the region.
Methods
Oropharyngeal swabs, demographic data and clinical characteristics were obtained from individuals with influenza‐like illness in 10 Latin‐American countries between 2006–2010. Specimens were analyzed with culture and molecular methods.
Results
A total of 30 561 individuals were enrolled; 991 (3·2%) were HPIV positive. Most infected participants were male (53·7%) and under 5 years of age (68·7%). The HPIV type most frequently isolated was HPIV‐3 (403, 40·7%). In 66/2007 (3·3%) hospitalized individuals, HPIV was identified. The most frequent symptoms at enrollment were cough and rhinorrhea. We identified certain patterns for HPIV‐1, ‐2 and ‐3 in specific cities. Phylogenetic analysis revealed a homogeneous distribution in the region.
Conclusions
In the current scenario, no vaccine or treatment is available for this pathogen. Our results contribute to the scarce epidemiologic and phylogenetic information of HPIV in the region that could support the development of specific management. |
| doi_str_mv | 10.1111/irv.12211 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4186470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A711798054</galeid><sourcerecordid>A711798054</sourcerecordid><originalsourceid>FETCH-LOGICAL-g4081-170d6b336545bd96a10b36bfcef5d6bc5778b4db49d361efd4b69a8a53239c863</originalsourceid><addsrcrecordid>eNptkt9KHDEUxoO0qF298AVKoDe92TX_J3MjLIutglBoq7chM8msqZnMNtms2CsfoeAb-iRmXV0qNLnI4Xy_83GSHACOMJrgso5dXE0wIRjvgH1ccTQmgtfvtjFDe-BDSr8Q4kJytgv2CCNSECb3QT7LvQ5woaN2ofPZhj8arlzMCbp1eulsWCZ465bXcAs83v_17sZC532wKcEuDj2cFTBqD3Uw8MeQCz_tbXSthiZHF-aQICQe7x8IwugAvO-0T_bw5RyByy-nP2dn44tvX89n04vxnCGJx7hCRjSUCs54Y2qhMWqoaLrWdrwILa8q2TDTsNpQgW1nWCNqLTWnhNatFHQETja-i9z01rSbFtUiul7HOzVop94qwV2r-bBSDEvBKlQMPr8YxOF3tmmpepda670OdshJYY4Y45xRXtBPG3SuvVXlrYbi2K5xNa0wrmqJCjcCk_9QZRvbu3YItnMl_6bg479X2Pb--oUFON4At6XybqtjpNazocpsqOfZUOffr54D-gTapa14</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504455435</pqid></control><display><type>article</type><title>Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><creator>Villaran, Manuel V. ; García, Josefina ; Gomez, Jorge ; Arango, Ana E. ; Gonzales, Marina ; Chicaiza, Wilson ; Alemán, Washington ; Lorenzana de Rivera, Ivette ; Sanchez, Felix ; Aguayo, Nicolas ; Kochel, Tadeusz J. ; Halsey, Eric S.</creator><creatorcontrib>Villaran, Manuel V. ; García, Josefina ; Gomez, Jorge ; Arango, Ana E. ; Gonzales, Marina ; Chicaiza, Wilson ; Alemán, Washington ; Lorenzana de Rivera, Ivette ; Sanchez, Felix ; Aguayo, Nicolas ; Kochel, Tadeusz J. ; Halsey, Eric S.</creatorcontrib><description>Background
Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America.
Objective
Provide epidemiologic and phylogenetic information about HPIVs that circulated in Latin America between 2006 and 2010 to better characterize the extent and variability of this respiratory virus in the region.
Methods
Oropharyngeal swabs, demographic data and clinical characteristics were obtained from individuals with influenza‐like illness in 10 Latin‐American countries between 2006–2010. Specimens were analyzed with culture and molecular methods.
Results
A total of 30 561 individuals were enrolled; 991 (3·2%) were HPIV positive. Most infected participants were male (53·7%) and under 5 years of age (68·7%). The HPIV type most frequently isolated was HPIV‐3 (403, 40·7%). In 66/2007 (3·3%) hospitalized individuals, HPIV was identified. The most frequent symptoms at enrollment were cough and rhinorrhea. We identified certain patterns for HPIV‐1, ‐2 and ‐3 in specific cities. Phylogenetic analysis revealed a homogeneous distribution in the region.
Conclusions
In the current scenario, no vaccine or treatment is available for this pathogen. Our results contribute to the scarce epidemiologic and phylogenetic information of HPIV in the region that could support the development of specific management.</description><identifier>ISSN: 1750-2640</identifier><identifier>EISSN: 1750-2659</identifier><identifier>DOI: 10.1111/irv.12211</identifier><identifier>PMID: 24286248</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Analysis ; Care and treatment ; Central America - epidemiology ; Child ; Child, Preschool ; Cluster Analysis ; Epidemiology ; Female ; Genotype ; Genotyping Techniques ; Humans ; Infant ; Influenza ; Latin America ; Male ; Middle Aged ; Molecular Sequence Data ; Original ; Oropharynx - virology ; parainfluenza virus ; Paramyxoviridae - classification ; Paramyxoviridae - genetics ; Paramyxoviridae - isolation & purification ; Paramyxoviridae Infections - epidemiology ; Paramyxoviridae Infections - pathology ; Paramyxoviridae Infections - virology ; phylogenetics ; Phylogeny ; Sequence Analysis, DNA ; South America - epidemiology ; Virus Cultivation ; Young Adult</subject><ispartof>Influenza and other respiratory viruses, 2014-03, Vol.8 (2), p.217-227</ispartof><rights>2013 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186470/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186470/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11560,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24286248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villaran, Manuel V.</creatorcontrib><creatorcontrib>García, Josefina</creatorcontrib><creatorcontrib>Gomez, Jorge</creatorcontrib><creatorcontrib>Arango, Ana E.</creatorcontrib><creatorcontrib>Gonzales, Marina</creatorcontrib><creatorcontrib>Chicaiza, Wilson</creatorcontrib><creatorcontrib>Alemán, Washington</creatorcontrib><creatorcontrib>Lorenzana de Rivera, Ivette</creatorcontrib><creatorcontrib>Sanchez, Felix</creatorcontrib><creatorcontrib>Aguayo, Nicolas</creatorcontrib><creatorcontrib>Kochel, Tadeusz J.</creatorcontrib><creatorcontrib>Halsey, Eric S.</creatorcontrib><title>Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010</title><title>Influenza and other respiratory viruses</title><addtitle>Influenza Other Respir Viruses</addtitle><description>Background
Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America.
Objective
Provide epidemiologic and phylogenetic information about HPIVs that circulated in Latin America between 2006 and 2010 to better characterize the extent and variability of this respiratory virus in the region.
Methods
Oropharyngeal swabs, demographic data and clinical characteristics were obtained from individuals with influenza‐like illness in 10 Latin‐American countries between 2006–2010. Specimens were analyzed with culture and molecular methods.
Results
A total of 30 561 individuals were enrolled; 991 (3·2%) were HPIV positive. Most infected participants were male (53·7%) and under 5 years of age (68·7%). The HPIV type most frequently isolated was HPIV‐3 (403, 40·7%). In 66/2007 (3·3%) hospitalized individuals, HPIV was identified. The most frequent symptoms at enrollment were cough and rhinorrhea. We identified certain patterns for HPIV‐1, ‐2 and ‐3 in specific cities. Phylogenetic analysis revealed a homogeneous distribution in the region.
Conclusions
In the current scenario, no vaccine or treatment is available for this pathogen. Our results contribute to the scarce epidemiologic and phylogenetic information of HPIV in the region that could support the development of specific management.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Care and treatment</subject><subject>Central America - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotyping Techniques</subject><subject>Humans</subject><subject>Infant</subject><subject>Influenza</subject><subject>Latin America</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Original</subject><subject>Oropharynx - virology</subject><subject>parainfluenza virus</subject><subject>Paramyxoviridae - classification</subject><subject>Paramyxoviridae - genetics</subject><subject>Paramyxoviridae - isolation & purification</subject><subject>Paramyxoviridae Infections - epidemiology</subject><subject>Paramyxoviridae Infections - pathology</subject><subject>Paramyxoviridae Infections - virology</subject><subject>phylogenetics</subject><subject>Phylogeny</subject><subject>Sequence Analysis, DNA</subject><subject>South America - epidemiology</subject><subject>Virus Cultivation</subject><subject>Young Adult</subject><issn>1750-2640</issn><issn>1750-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNptkt9KHDEUxoO0qF298AVKoDe92TX_J3MjLIutglBoq7chM8msqZnMNtms2CsfoeAb-iRmXV0qNLnI4Xy_83GSHACOMJrgso5dXE0wIRjvgH1ccTQmgtfvtjFDe-BDSr8Q4kJytgv2CCNSECb3QT7LvQ5woaN2ofPZhj8arlzMCbp1eulsWCZ465bXcAs83v_17sZC532wKcEuDj2cFTBqD3Uw8MeQCz_tbXSthiZHF-aQICQe7x8IwugAvO-0T_bw5RyByy-nP2dn44tvX89n04vxnCGJx7hCRjSUCs54Y2qhMWqoaLrWdrwILa8q2TDTsNpQgW1nWCNqLTWnhNatFHQETja-i9z01rSbFtUiul7HOzVop94qwV2r-bBSDEvBKlQMPr8YxOF3tmmpepda670OdshJYY4Y45xRXtBPG3SuvVXlrYbi2K5xNa0wrmqJCjcCk_9QZRvbu3YItnMl_6bg479X2Pb--oUFON4At6XybqtjpNazocpsqOfZUOffr54D-gTapa14</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Villaran, Manuel V.</creator><creator>García, Josefina</creator><creator>Gomez, Jorge</creator><creator>Arango, Ana E.</creator><creator>Gonzales, Marina</creator><creator>Chicaiza, Wilson</creator><creator>Alemán, Washington</creator><creator>Lorenzana de Rivera, Ivette</creator><creator>Sanchez, Felix</creator><creator>Aguayo, Nicolas</creator><creator>Kochel, Tadeusz J.</creator><creator>Halsey, Eric S.</creator><general>John Wiley & Sons, Inc</general><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010</title><author>Villaran, Manuel V. ; García, Josefina ; Gomez, Jorge ; Arango, Ana E. ; Gonzales, Marina ; Chicaiza, Wilson ; Alemán, Washington ; Lorenzana de Rivera, Ivette ; Sanchez, Felix ; Aguayo, Nicolas ; Kochel, Tadeusz J. ; Halsey, Eric S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g4081-170d6b336545bd96a10b36bfcef5d6bc5778b4db49d361efd4b69a8a53239c863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Care and treatment</topic><topic>Central America - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cluster Analysis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotyping Techniques</topic><topic>Humans</topic><topic>Infant</topic><topic>Influenza</topic><topic>Latin America</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Original</topic><topic>Oropharynx - virology</topic><topic>parainfluenza virus</topic><topic>Paramyxoviridae - classification</topic><topic>Paramyxoviridae - genetics</topic><topic>Paramyxoviridae - isolation & purification</topic><topic>Paramyxoviridae Infections - epidemiology</topic><topic>Paramyxoviridae Infections - pathology</topic><topic>Paramyxoviridae Infections - virology</topic><topic>phylogenetics</topic><topic>Phylogeny</topic><topic>Sequence Analysis, DNA</topic><topic>South America - epidemiology</topic><topic>Virus Cultivation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villaran, Manuel V.</creatorcontrib><creatorcontrib>García, Josefina</creatorcontrib><creatorcontrib>Gomez, Jorge</creatorcontrib><creatorcontrib>Arango, Ana E.</creatorcontrib><creatorcontrib>Gonzales, Marina</creatorcontrib><creatorcontrib>Chicaiza, Wilson</creatorcontrib><creatorcontrib>Alemán, Washington</creatorcontrib><creatorcontrib>Lorenzana de Rivera, Ivette</creatorcontrib><creatorcontrib>Sanchez, Felix</creatorcontrib><creatorcontrib>Aguayo, Nicolas</creatorcontrib><creatorcontrib>Kochel, Tadeusz J.</creatorcontrib><creatorcontrib>Halsey, Eric S.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Influenza and other respiratory viruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villaran, Manuel V.</au><au>García, Josefina</au><au>Gomez, Jorge</au><au>Arango, Ana E.</au><au>Gonzales, Marina</au><au>Chicaiza, Wilson</au><au>Alemán, Washington</au><au>Lorenzana de Rivera, Ivette</au><au>Sanchez, Felix</au><au>Aguayo, Nicolas</au><au>Kochel, Tadeusz J.</au><au>Halsey, Eric S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010</atitle><jtitle>Influenza and other respiratory viruses</jtitle><addtitle>Influenza Other Respir Viruses</addtitle><date>2014-03</date><risdate>2014</risdate><volume>8</volume><issue>2</issue><spage>217</spage><epage>227</epage><pages>217-227</pages><issn>1750-2640</issn><eissn>1750-2659</eissn><abstract>Background
Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America.
Objective
Provide epidemiologic and phylogenetic information about HPIVs that circulated in Latin America between 2006 and 2010 to better characterize the extent and variability of this respiratory virus in the region.
Methods
Oropharyngeal swabs, demographic data and clinical characteristics were obtained from individuals with influenza‐like illness in 10 Latin‐American countries between 2006–2010. Specimens were analyzed with culture and molecular methods.
Results
A total of 30 561 individuals were enrolled; 991 (3·2%) were HPIV positive. Most infected participants were male (53·7%) and under 5 years of age (68·7%). The HPIV type most frequently isolated was HPIV‐3 (403, 40·7%). In 66/2007 (3·3%) hospitalized individuals, HPIV was identified. The most frequent symptoms at enrollment were cough and rhinorrhea. We identified certain patterns for HPIV‐1, ‐2 and ‐3 in specific cities. Phylogenetic analysis revealed a homogeneous distribution in the region.
Conclusions
In the current scenario, no vaccine or treatment is available for this pathogen. Our results contribute to the scarce epidemiologic and phylogenetic information of HPIV in the region that could support the development of specific management.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>24286248</pmid><doi>10.1111/irv.12211</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Adolescent Adult Aged Analysis Care and treatment Central America - epidemiology Child Child, Preschool Cluster Analysis Epidemiology Female Genotype Genotyping Techniques Humans Infant Influenza Latin America Male Middle Aged Molecular Sequence Data Original Oropharynx - virology parainfluenza virus Paramyxoviridae - classification Paramyxoviridae - genetics Paramyxoviridae - isolation & purification Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - pathology Paramyxoviridae Infections - virology phylogenetics Phylogeny Sequence Analysis, DNA South America - epidemiology Virus Cultivation Young Adult |
| title | Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010 |
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