Modeling of age‐dependent amyloid accumulation and γ‐secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition

According to the “amyloid hypothesis,” accumulation of amyloid beta (Aβ) peptides in the brain is linked to the development of Alzheimer's disease. The aims of this investigation were to develop a model for the age‐dependent amyloid accumulation and to quantify the age‐ and treatment‐duration‐d...

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