Polymeric nanoparticles: Potent vectors for vaccine delivery targeting cancer and infectious diseases
Nanocarriers with various compositions and biological properties have been extensively applied for in vitro/in vivo drug and gene delivery. The family of nanocarriers includes polymeric nanoparticles, lipid-based carriers (liposomes/micelles), dendrimers, carbon nanotubes, and gold nanoparticles (na...
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| Veröffentlicht in: | Human vaccines & immunotherapeutics 2014-02, Vol.10 (2), p.321-332 |
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| container_title | Human vaccines & immunotherapeutics |
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| creator | Bolhassani, Azam Javanzad, Shabnam Saleh, Tayebeh Hashemi, Mehrdad Aghasadeghi, Mohammad Reza Sadat, Seyed Mehdi |
| description | Nanocarriers with various compositions and biological properties have been extensively applied for in vitro/in vivo drug and gene delivery. The family of nanocarriers includes polymeric nanoparticles, lipid-based carriers (liposomes/micelles), dendrimers, carbon nanotubes, and gold nanoparticles (nanoshells/nanocages). Among different delivery systems, polymeric carriers have several properties such as: easy to synthesize, inexpensive, biocompatible, biodegradable, non-immunogenic, non-toxic, and water soluble. In addition, cationic polymers seem to produce more stable complexes led to a more protection during cellular trafficking than cationic lipids.
Nanoparticles often show significant adjuvant effects in vaccine delivery since they may be easily taken up by antigen presenting cells (APCs). Natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles. The development of new adjuvants or delivery systems for DNA and protein immunization is an expanding research field. This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems. |
| doi_str_mv | 10.4161/hv.26796 |
| format | Article |
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Nanoparticles often show significant adjuvant effects in vaccine delivery since they may be easily taken up by antigen presenting cells (APCs). Natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles. The development of new adjuvants or delivery systems for DNA and protein immunization is an expanding research field. This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems.</description><identifier>ISSN: 2164-5515</identifier><identifier>EISSN: 2164-554X</identifier><identifier>DOI: 10.4161/hv.26796</identifier><identifier>PMID: 24128651</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject><![CDATA[Adjuvants, Immunologic - administration & dosage ; Communicable Disease Control ; Drug Carriers - administration & dosage ; gene therapy ; Humans ; Nanoparticles - administration & dosage ; natural polymer ; Neoplasms - prevention & control ; non-viral vectors ; Polymers - administration & dosage ; Review ; synthetic polymer ; vaccine delivery ; Vaccines - administration & dosage ; Vaccines - immunology ; Vaccines - pharmacokinetics]]></subject><ispartof>Human vaccines & immunotherapeutics, 2014-02, Vol.10 (2), p.321-332</ispartof><rights>Copyright © 2014 Landes Bioscience 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-4feac10db9c1688c4d6f45b4b12277c9b12f0ad26f9c1d56c333973935b4e9453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185908/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185908/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24128651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolhassani, Azam</creatorcontrib><creatorcontrib>Javanzad, Shabnam</creatorcontrib><creatorcontrib>Saleh, Tayebeh</creatorcontrib><creatorcontrib>Hashemi, Mehrdad</creatorcontrib><creatorcontrib>Aghasadeghi, Mohammad Reza</creatorcontrib><creatorcontrib>Sadat, Seyed Mehdi</creatorcontrib><title>Polymeric nanoparticles: Potent vectors for vaccine delivery targeting cancer and infectious diseases</title><title>Human vaccines & immunotherapeutics</title><addtitle>Hum Vaccin Immunother</addtitle><description>Nanocarriers with various compositions and biological properties have been extensively applied for in vitro/in vivo drug and gene delivery. The family of nanocarriers includes polymeric nanoparticles, lipid-based carriers (liposomes/micelles), dendrimers, carbon nanotubes, and gold nanoparticles (nanoshells/nanocages). Among different delivery systems, polymeric carriers have several properties such as: easy to synthesize, inexpensive, biocompatible, biodegradable, non-immunogenic, non-toxic, and water soluble. In addition, cationic polymers seem to produce more stable complexes led to a more protection during cellular trafficking than cationic lipids.
Nanoparticles often show significant adjuvant effects in vaccine delivery since they may be easily taken up by antigen presenting cells (APCs). Natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles. The development of new adjuvants or delivery systems for DNA and protein immunization is an expanding research field. This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Communicable Disease Control</subject><subject>Drug Carriers - administration & dosage</subject><subject>gene therapy</subject><subject>Humans</subject><subject>Nanoparticles - administration & dosage</subject><subject>natural polymer</subject><subject>Neoplasms - prevention & control</subject><subject>non-viral vectors</subject><subject>Polymers - administration & dosage</subject><subject>Review</subject><subject>synthetic polymer</subject><subject>vaccine delivery</subject><subject>Vaccines - administration & dosage</subject><subject>Vaccines - immunology</subject><subject>Vaccines - pharmacokinetics</subject><issn>2164-5515</issn><issn>2164-554X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LxDAQhoMo7rIuePMmHr10zXebiyDL-gELelDwFtI0sZG2WZJa2X9vdLUozmUG5pln4AXgGMEFRRxd1MMC81zwPTDFiNOMMfq8P86ITcA8xleYKoeYcn4IJpgiXHCGpuDkwTfb1gSnzzrV-Y0KvdONiUfgwKommvl3n4Gn69Xj8jZb39_cLa_WmSaU9Bm1RmkEq1JoxItC04pbykpaIozzXIvULVQV5jYBFeOaECJyIkhijKCMzMDlzrt5K1tTadP1QTVyE1yrwlZ65eTfTedq-eIHSVHBBCyS4Hwn0MHHGIwdbxGUn_nIepBf-ST09PevEfxJIwFkB7jO-tCqdx-aSvZq2_hgg-q0i5L8034A4dxxvw</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Bolhassani, Azam</creator><creator>Javanzad, Shabnam</creator><creator>Saleh, Tayebeh</creator><creator>Hashemi, Mehrdad</creator><creator>Aghasadeghi, Mohammad Reza</creator><creator>Sadat, Seyed Mehdi</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Polymeric nanoparticles</title><author>Bolhassani, Azam ; Javanzad, Shabnam ; Saleh, Tayebeh ; Hashemi, Mehrdad ; Aghasadeghi, Mohammad Reza ; Sadat, Seyed Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-4feac10db9c1688c4d6f45b4b12277c9b12f0ad26f9c1d56c333973935b4e9453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Communicable Disease Control</topic><topic>Drug Carriers - administration & dosage</topic><topic>gene therapy</topic><topic>Humans</topic><topic>Nanoparticles - administration & dosage</topic><topic>natural polymer</topic><topic>Neoplasms - prevention & control</topic><topic>non-viral vectors</topic><topic>Polymers - administration & dosage</topic><topic>Review</topic><topic>synthetic polymer</topic><topic>vaccine delivery</topic><topic>Vaccines - administration & dosage</topic><topic>Vaccines - immunology</topic><topic>Vaccines - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolhassani, Azam</creatorcontrib><creatorcontrib>Javanzad, Shabnam</creatorcontrib><creatorcontrib>Saleh, Tayebeh</creatorcontrib><creatorcontrib>Hashemi, Mehrdad</creatorcontrib><creatorcontrib>Aghasadeghi, Mohammad Reza</creatorcontrib><creatorcontrib>Sadat, Seyed Mehdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human vaccines & immunotherapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolhassani, Azam</au><au>Javanzad, Shabnam</au><au>Saleh, Tayebeh</au><au>Hashemi, Mehrdad</au><au>Aghasadeghi, Mohammad Reza</au><au>Sadat, Seyed Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric nanoparticles: Potent vectors for vaccine delivery targeting cancer and infectious diseases</atitle><jtitle>Human vaccines & immunotherapeutics</jtitle><addtitle>Hum Vaccin Immunother</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>10</volume><issue>2</issue><spage>321</spage><epage>332</epage><pages>321-332</pages><issn>2164-5515</issn><eissn>2164-554X</eissn><abstract>Nanocarriers with various compositions and biological properties have been extensively applied for in vitro/in vivo drug and gene delivery. 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Nanoparticles often show significant adjuvant effects in vaccine delivery since they may be easily taken up by antigen presenting cells (APCs). Natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles. The development of new adjuvants or delivery systems for DNA and protein immunization is an expanding research field. This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>24128651</pmid><doi>10.4161/hv.26796</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic - administration & dosage Communicable Disease Control Drug Carriers - administration & dosage gene therapy Humans Nanoparticles - administration & dosage natural polymer Neoplasms - prevention & control non-viral vectors Polymers - administration & dosage Review synthetic polymer vaccine delivery Vaccines - administration & dosage Vaccines - immunology Vaccines - pharmacokinetics |
| title | Polymeric nanoparticles: Potent vectors for vaccine delivery targeting cancer and infectious diseases |
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