Lipid catabolism via CPT1 as a therapeutic target for prostate cancer

Prostate cancer is the most commonly diagnosed malignancy among Western men and accounts for the second leading cause of cancer-related deaths. Prostate cancer tends to grow slowly and recent studies suggest that it relies on lipid fuel more than on aerobic glycolysis. However, the biochemical mecha...

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Veröffentlicht in:	Molecular cancer therapeutics 2014-10, Vol.13 (10), p.2361-2371
Hauptverfasser:	Schlaepfer, Isabel R, Rider, Leah, Rodrigues, Lindsey Ulkus, Gijón, Miguel A, Pac, Colton T, Romero, Lina, Cimic, Adela, Sirintrapun, S Joseph, Glodé, L Michael, Eckel, Robert H, Cramer, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Carnitine O-Palmitoyltransferase - antagonists & inhibitors Cell Line, Tumor Cell Proliferation - drug effects Down-Regulation - drug effects Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Epoxy Compounds - administration & dosage Epoxy Compounds - pharmacology Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Lactones - administration & dosage Lactones - pharmacology Lipid Metabolism - drug effects Male Metabolism Mice Mice, Nude Oxidation-Reduction - drug effects Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Random Allocation Signal Transduction Xenograft Model Antitumor Assays
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