Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
Background: The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) protein expression in primary UMs (PUMs) that show both ‘typical’ and ‘atypical’ clinical cour...
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| Veröffentlicht in: | British journal of cancer 2014-09, Vol.111 (7), p.1373-1380 |
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| creator | Kalirai, H Dodson, A Faqir, S Damato, B E Coupland, S E |
| description | Background:
The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) protein expression in primary UMs (PUMs) that show both ‘typical’ and ‘atypical’ clinical courses according to their chromosome 3 status, and secondary hepatic metastatic UM (MUM), correlating the results with histological, clinical and survival data.
Methods:
Nuclear BAP1 expression was immunohistochemically assessed in tissue microarrays (TMAs) of: (a) 68 PUM patients, who had been treated surgically; and (b) 13 MUM patients, with 5 cases being paired with primary tumour tissue. All cases were fully annotated. The percentage of tumour cell nuclei staining positively for BAP1 was scored by independent observers.
Results:
Nuclear BAP1 protein expression was absent in 35 out of 68 (51%) PUM patients, correlating strongly with poor prognostic clinicopathological and genetic parameters and reduced survival (Log rank,
P |
| doi_str_mv | 10.1038/bjc.2014.417 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4183849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1565503611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-1059f5090e96b115d1ace259a2c39b28906d39d7cf6fffe3d92c61ca367cf02e3</originalsourceid><addsrcrecordid>eNptkU1v1DAQhi0EotvCjTOyhJB6IIs_4iS-VCoVX9JKcIBzNOtMdr1N7MV2Cv0P_Ggc7VIK4jR6PY9m3vFLyDPOlpzJ5vV6Z5aC8XJZ8voBWXAlRcEbUT8kC8ZYXTAt2Ak5jXGXpWZN_ZicCMVUI8t6QX6uwFxT39M3l5853Qef0DqKP_YBY7Te0aymG4SBjjiA8yNQGynE6I2FhB39btM2QyYgxCxHTBATJGtosPGaguvoFiKdkh1sup3HBZ-Fw3nZxvk4owlzcZsn5FEPQ8Snx3pGvr57--XqQ7H69P7j1eWqMEqxVHCmdK_yLairNeeq42BQKA3CSL0WjWZVJ3VXm77q-x5lp4WpuAFZ5ScmUJ6Ri8Pc_bQesTPoUoCh3Qc7QrhtPdj2746z23bjb9qSN7IpdR5wfhwQ_Lcpm29HGw0O-YfQT7HlqspOZcV5Rl_8g-78FFw-b6ZKWZdVqTL16kCZ4GMM2N-Z4aydY25zzO0cc_ZQZ_z5_QPu4N-5ZuDlEYBoYOgDOGPjH67Rkh32Fgcu5pbbYLjn7n-LfwGkecH-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564374645</pqid></control><display><type>article</type><title>Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing</title><source>PubMed Central Free</source><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kalirai, H ; Dodson, A ; Faqir, S ; Damato, B E ; Coupland, S E</creator><creatorcontrib>Kalirai, H ; Dodson, A ; Faqir, S ; Damato, B E ; Coupland, S E</creatorcontrib><description>Background:
The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) protein expression in primary UMs (PUMs) that show both ‘typical’ and ‘atypical’ clinical courses according to their chromosome 3 status, and secondary hepatic metastatic UM (MUM), correlating the results with histological, clinical and survival data.
Methods:
Nuclear BAP1 expression was immunohistochemically assessed in tissue microarrays (TMAs) of: (a) 68 PUM patients, who had been treated surgically; and (b) 13 MUM patients, with 5 cases being paired with primary tumour tissue. All cases were fully annotated. The percentage of tumour cell nuclei staining positively for BAP1 was scored by independent observers.
Results:
Nuclear BAP1 protein expression was absent in 35 out of 68 (51%) PUM patients, correlating strongly with poor prognostic clinicopathological and genetic parameters and reduced survival (Log rank,
P
<0.001). Lack of nBAP1 expression importantly identified a subset of ‘atypical’ PUM patients with disomy of chromosome 3 but with unexpected metastatic relapse. Nuclear BAP1 expression was absent in 10 out of 13 (77%) MUM and expression was concordant in all paired PUM and MUM patients.
Conclusions:
Absent nBAP1 protein expression is an independent survival predictor for UM patients, easily examined using immunohistochemistry.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2014.417</identifier><identifier>PMID: 25058347</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/68 ; 692/699/67/1484 ; 692/699/67/322 ; 692/700/1750 ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Cell cycle ; Chromosomes ; Drug Resistance ; Epidemiology ; Female ; Humans ; Kaplan-Meier Estimate ; Liver ; Liver Neoplasms - metabolism ; Liver Neoplasms - secondary ; Male ; Medical prognosis ; Medical research ; Medical sciences ; Melanoma ; Melanoma - metabolism ; Melanoma - mortality ; Melanoma - secondary ; Metastasis ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Mutation ; Oncology ; Ophthalmology ; Prognosis ; Proportional Hazards Models ; Protein expression ; Proteins ; Risk Factors ; Tumor Suppressor Proteins - metabolism ; Tumors ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus ; Ubiquitin Thiolesterase - metabolism ; Uveal Neoplasms - metabolism ; Uveal Neoplasms - mortality ; Uveal Neoplasms - pathology ; Young Adult</subject><ispartof>British journal of cancer, 2014-09, Vol.111 (7), p.1373-1380</ispartof><rights>The Author(s) 2014</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 23, 2014</rights><rights>Copyright © 2014 Cancer Research UK 2014 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-1059f5090e96b115d1ace259a2c39b28906d39d7cf6fffe3d92c61ca367cf02e3</citedby><cites>FETCH-LOGICAL-c550t-1059f5090e96b115d1ace259a2c39b28906d39d7cf6fffe3d92c61ca367cf02e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183849/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183849/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28930645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25058347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalirai, H</creatorcontrib><creatorcontrib>Dodson, A</creatorcontrib><creatorcontrib>Faqir, S</creatorcontrib><creatorcontrib>Damato, B E</creatorcontrib><creatorcontrib>Coupland, S E</creatorcontrib><title>Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) protein expression in primary UMs (PUMs) that show both ‘typical’ and ‘atypical’ clinical courses according to their chromosome 3 status, and secondary hepatic metastatic UM (MUM), correlating the results with histological, clinical and survival data.
Methods:
Nuclear BAP1 expression was immunohistochemically assessed in tissue microarrays (TMAs) of: (a) 68 PUM patients, who had been treated surgically; and (b) 13 MUM patients, with 5 cases being paired with primary tumour tissue. All cases were fully annotated. The percentage of tumour cell nuclei staining positively for BAP1 was scored by independent observers.
Results:
Nuclear BAP1 protein expression was absent in 35 out of 68 (51%) PUM patients, correlating strongly with poor prognostic clinicopathological and genetic parameters and reduced survival (Log rank,
P
<0.001). Lack of nBAP1 expression importantly identified a subset of ‘atypical’ PUM patients with disomy of chromosome 3 but with unexpected metastatic relapse. Nuclear BAP1 expression was absent in 10 out of 13 (77%) MUM and expression was concordant in all paired PUM and MUM patients.
Conclusions:
Absent nBAP1 protein expression is an independent survival predictor for UM patients, easily examined using immunohistochemistry.</description><subject>631/67/68</subject><subject>692/699/67/1484</subject><subject>692/699/67/322</subject><subject>692/700/1750</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cell cycle</subject><subject>Chromosomes</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - mortality</subject><subject>Melanoma - secondary</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Ophthalmology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Tumor Suppressor Proteins - metabolism</subject><subject>Tumors</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><subject>Ubiquitin Thiolesterase - metabolism</subject><subject>Uveal Neoplasms - metabolism</subject><subject>Uveal Neoplasms - mortality</subject><subject>Uveal Neoplasms - pathology</subject><subject>Young Adult</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkU1v1DAQhi0EotvCjTOyhJB6IIs_4iS-VCoVX9JKcIBzNOtMdr1N7MV2Cv0P_Ggc7VIK4jR6PY9m3vFLyDPOlpzJ5vV6Z5aC8XJZ8voBWXAlRcEbUT8kC8ZYXTAt2Ak5jXGXpWZN_ZicCMVUI8t6QX6uwFxT39M3l5853Qef0DqKP_YBY7Te0aymG4SBjjiA8yNQGynE6I2FhB39btM2QyYgxCxHTBATJGtosPGaguvoFiKdkh1sup3HBZ-Fw3nZxvk4owlzcZsn5FEPQ8Snx3pGvr57--XqQ7H69P7j1eWqMEqxVHCmdK_yLairNeeq42BQKA3CSL0WjWZVJ3VXm77q-x5lp4WpuAFZ5ScmUJ6Ri8Pc_bQesTPoUoCh3Qc7QrhtPdj2746z23bjb9qSN7IpdR5wfhwQ_Lcpm29HGw0O-YfQT7HlqspOZcV5Rl_8g-78FFw-b6ZKWZdVqTL16kCZ4GMM2N-Z4aydY25zzO0cc_ZQZ_z5_QPu4N-5ZuDlEYBoYOgDOGPjH67Rkh32Fgcu5pbbYLjn7n-LfwGkecH-</recordid><startdate>20140923</startdate><enddate>20140923</enddate><creator>Kalirai, H</creator><creator>Dodson, A</creator><creator>Faqir, S</creator><creator>Damato, B E</creator><creator>Coupland, S E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140923</creationdate><title>Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing</title><author>Kalirai, H ; Dodson, A ; Faqir, S ; Damato, B E ; Coupland, S E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-1059f5090e96b115d1ace259a2c39b28906d39d7cf6fffe3d92c61ca367cf02e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/67/68</topic><topic>692/699/67/1484</topic><topic>692/699/67/322</topic><topic>692/700/1750</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cell cycle</topic><topic>Chromosomes</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Melanoma</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - mortality</topic><topic>Melanoma - secondary</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Ophthalmology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Tumor Suppressor Proteins - metabolism</topic><topic>Tumors</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><topic>Ubiquitin Thiolesterase - metabolism</topic><topic>Uveal Neoplasms - metabolism</topic><topic>Uveal Neoplasms - mortality</topic><topic>Uveal Neoplasms - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalirai, H</creatorcontrib><creatorcontrib>Dodson, A</creatorcontrib><creatorcontrib>Faqir, S</creatorcontrib><creatorcontrib>Damato, B E</creatorcontrib><creatorcontrib>Coupland, S E</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalirai, H</au><au>Dodson, A</au><au>Faqir, S</au><au>Damato, B E</au><au>Coupland, S E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2014-09-23</date><risdate>2014</risdate><volume>111</volume><issue>7</issue><spage>1373</spage><epage>1380</epage><pages>1373-1380</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) protein expression in primary UMs (PUMs) that show both ‘typical’ and ‘atypical’ clinical courses according to their chromosome 3 status, and secondary hepatic metastatic UM (MUM), correlating the results with histological, clinical and survival data.
Methods:
Nuclear BAP1 expression was immunohistochemically assessed in tissue microarrays (TMAs) of: (a) 68 PUM patients, who had been treated surgically; and (b) 13 MUM patients, with 5 cases being paired with primary tumour tissue. All cases were fully annotated. The percentage of tumour cell nuclei staining positively for BAP1 was scored by independent observers.
Results:
Nuclear BAP1 protein expression was absent in 35 out of 68 (51%) PUM patients, correlating strongly with poor prognostic clinicopathological and genetic parameters and reduced survival (Log rank,
P
<0.001). Lack of nBAP1 expression importantly identified a subset of ‘atypical’ PUM patients with disomy of chromosome 3 but with unexpected metastatic relapse. Nuclear BAP1 expression was absent in 10 out of 13 (77%) MUM and expression was concordant in all paired PUM and MUM patients.
Conclusions:
Absent nBAP1 protein expression is an independent survival predictor for UM patients, easily examined using immunohistochemistry.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25058347</pmid><doi>10.1038/bjc.2014.417</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/68 692/699/67/1484 692/699/67/322 692/700/1750 Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Chromosomes Drug Resistance Epidemiology Female Humans Kaplan-Meier Estimate Liver Liver Neoplasms - metabolism Liver Neoplasms - secondary Male Medical prognosis Medical research Medical sciences Melanoma Melanoma - metabolism Melanoma - mortality Melanoma - secondary Metastasis Middle Aged Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Oncology Ophthalmology Prognosis Proportional Hazards Models Protein expression Proteins Risk Factors Tumor Suppressor Proteins - metabolism Tumors Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Ubiquitin Thiolesterase - metabolism Uveal Neoplasms - metabolism Uveal Neoplasms - mortality Uveal Neoplasms - pathology Young Adult |
| title | Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing |
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