PATHOME: an algorithm for accurately detecting differentially expressed subpathways

The translation of high-throughput gene expression data into biologically meaningful information remains a bottleneck. We developed a novel computational algorithm, PATHOME, for detecting differentially expressed biological pathways. This algorithm employs straightforward statistical tests to evalua...

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Veröffentlicht in:	Oncogene 2014-10, Vol.33 (41), p.4941-4951
Hauptverfasser:	Nam, S, Chang, H R, Kim, K-T, Kook, M-C, Hong, D, Kwon, C H, Jung, H R, Park, H S, Powis, G, Liang, H, Park, T, Kim, Y H
Format:	Artikel
Sprache:	eng
Schlagworte:	13 45 45/91 631/67/1504/1829 Algorithms Animals Apoptosis Cell Biology Cell Line, Tumor Computational biology Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic research Heterografts Human Genetics Humans Innovations Internal Medicine Medicine Medicine & Public Health Neoplasms, Experimental Oncology Original original-article Reproducibility of Results Signal Transduction Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcriptome Wnt Signaling Pathway
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