Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy
Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface‐engineered Au NRs with polyethylenimine are synthesized using...
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| Veröffentlicht in: | Advanced healthcare materials 2014-10, Vol.3 (10), p.1629-1637 |
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| creator | Shen, Jianliang Kim, Han-Cheon Mu, Chaofeng Gentile, Emanuela Mai, Junhua Wolfram, Joy Ji, Liang-nian Ferrari, Mauro Mao, Zong-wan Shen, Haifa |
| description | Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface‐engineered Au NRs with polyethylenimine are synthesized using a layer‐by‐layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near‐infrared (NIR) light, causing heat‐induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
Multifunctional polyethylenimine (PEI)–gold nanorods (Au NRs) are designed for delivery of small interfering RNA (siRNA) and thermal therapy. This platform shows anticancer activity, through simultaneous thermal ablation and suppression of oncogene expression. miRNA, messenger RNA; NIR, near infrared. |
| doi_str_mv | 10.1002/adhm.201400103 |
| format | Article |
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Multifunctional polyethylenimine (PEI)–gold nanorods (Au NRs) are designed for delivery of small interfering RNA (siRNA) and thermal therapy. This platform shows anticancer activity, through simultaneous thermal ablation and suppression of oncogene expression. miRNA, messenger RNA; NIR, near infrared.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201400103</identifier><identifier>PMID: 24692076</identifier><language>eng</language><publisher>Weinheim: Blackwell Publishing Ltd</publisher><subject>Animals ; Anticancer properties ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - therapy ; Cancer ; Cell Line, Tumor ; Cross-disciplinary physics: materials science; rheology ; Drug Delivery Systems - methods ; Exact sciences and technology ; Female ; Gene Silencing ; Genes ; Genetic Therapy - methods ; Gold ; Gold - administration & dosage ; Gold - chemistry ; gold nanorods ; Humans ; Hyperthermia, Induced - methods ; layer-by-layer assembly ; Macrophages - metabolism ; Materials science ; Medical research ; Medical sciences ; Mice ; Nanorods ; Nanoscale materials and structures: fabrication and characterization ; Nanotubes - chemistry ; Phototherapy - methods ; photothermal therapy ; Physics ; Polyethylenimine ; Ribonucleic acids ; RNA, Small Interfering - administration & dosage ; RNA, Small Interfering - chemistry ; RNA, Small Interfering - genetics ; siRNA ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Therapy</subject><ispartof>Advanced healthcare materials, 2014-10, Vol.3 (10), p.1629-1637</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 INIST-CNRS</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright WILEY-VCH Verlag GmbH & Co. KGaA, 69469 Weinheim, Germany, 2013. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6723-bf198f29498e98d3d5f459dbbd6fa0c8431166f1e72ccb43f9cb36b782918fde3</citedby><cites>FETCH-LOGICAL-c6723-bf198f29498e98d3d5f459dbbd6fa0c8431166f1e72ccb43f9cb36b782918fde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201400103$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201400103$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28867326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24692076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Jianliang</creatorcontrib><creatorcontrib>Kim, Han-Cheon</creatorcontrib><creatorcontrib>Mu, Chaofeng</creatorcontrib><creatorcontrib>Gentile, Emanuela</creatorcontrib><creatorcontrib>Mai, Junhua</creatorcontrib><creatorcontrib>Wolfram, Joy</creatorcontrib><creatorcontrib>Ji, Liang-nian</creatorcontrib><creatorcontrib>Ferrari, Mauro</creatorcontrib><creatorcontrib>Mao, Zong-wan</creatorcontrib><creatorcontrib>Shen, Haifa</creatorcontrib><title>Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy</title><title>Advanced healthcare materials</title><addtitle>Adv. Healthcare Mater</addtitle><description>Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface‐engineered Au NRs with polyethylenimine are synthesized using a layer‐by‐layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near‐infrared (NIR) light, causing heat‐induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
Multifunctional polyethylenimine (PEI)–gold nanorods (Au NRs) are designed for delivery of small interfering RNA (siRNA) and thermal therapy. This platform shows anticancer activity, through simultaneous thermal ablation and suppression of oncogene expression. miRNA, messenger RNA; NIR, near infrared.</description><subject>Animals</subject><subject>Anticancer properties</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Drug Delivery Systems - methods</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Gene Silencing</subject><subject>Genes</subject><subject>Genetic Therapy - methods</subject><subject>Gold</subject><subject>Gold - administration & dosage</subject><subject>Gold - chemistry</subject><subject>gold nanorods</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>layer-by-layer assembly</subject><subject>Macrophages - metabolism</subject><subject>Materials science</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nanorods</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nanotubes - chemistry</subject><subject>Phototherapy - methods</subject><subject>photothermal therapy</subject><subject>Physics</subject><subject>Polyethylenimine</subject><subject>Ribonucleic acids</subject><subject>RNA, Small Interfering - administration & dosage</subject><subject>RNA, Small Interfering - chemistry</subject><subject>RNA, Small Interfering - genetics</subject><subject>siRNA</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Therapy</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhUcIRKvSLUs0EkJiM8GPGT82SGmhCShNKwhCYmN5_GhcZsbBnink3-MoYShswJtr6X7n3GufLHsKwQQCgF5JvW4nCMASAAjwg-wYQY4KRCr-cLyX4Cg7jfEWpEMqSBh8nB2hknAEKDnOri6Hpnd26FTvfCebfOYbnS9l54PXMbc-5NF9WE7zmelM_tE1plOuu8llp_Prte99vzahTbpVqnKzfZI9srKJ5vRQT7JPF29X5_NicTV7dz5dFIpQhIvaQs4s4iVnhjONdWXLiuu61sRKoFiJISTEQkORUnWJLVc1JjVliENmtcEn2eu972aoW6OV6fogG7EJrpVhK7x04s9O59bixt-JEjIEKU0GLw8GwX8bTOxF66IyTSM744coIAWcVojz_0JhyUnFYEKf_4Xe-iGkf00UARwTygBJ1GRPqeBjDMaOe0MgdsmKXbJiTDYJnt1_7Yj_yjEBLw6AjEo2NsgUU_zNMUYoRjuO77nvKcntP8aK6Zv55f0lir3Wxd78GLUyfBXJnFbi83ImFvMvq2tw9l4Q_BMReMtK</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Shen, Jianliang</creator><creator>Kim, Han-Cheon</creator><creator>Mu, Chaofeng</creator><creator>Gentile, Emanuela</creator><creator>Mai, Junhua</creator><creator>Wolfram, Joy</creator><creator>Ji, Liang-nian</creator><creator>Ferrari, Mauro</creator><creator>Mao, Zong-wan</creator><creator>Shen, Haifa</creator><general>Blackwell Publishing Ltd</general><general>Wiley-VCH</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7QO</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201410</creationdate><title>Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy</title><author>Shen, Jianliang ; Kim, Han-Cheon ; Mu, Chaofeng ; Gentile, Emanuela ; Mai, Junhua ; Wolfram, Joy ; Ji, Liang-nian ; Ferrari, Mauro ; Mao, Zong-wan ; Shen, Haifa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6723-bf198f29498e98d3d5f459dbbd6fa0c8431166f1e72ccb43f9cb36b782918fde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anticancer properties</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cross-disciplinary physics: materials science; rheology</topic><topic>Drug Delivery Systems - methods</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Gene Silencing</topic><topic>Genes</topic><topic>Genetic Therapy - methods</topic><topic>Gold</topic><topic>Gold - administration & dosage</topic><topic>Gold - chemistry</topic><topic>gold nanorods</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>layer-by-layer assembly</topic><topic>Macrophages - metabolism</topic><topic>Materials science</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nanorods</topic><topic>Nanoscale materials and structures: fabrication and characterization</topic><topic>Nanotubes - chemistry</topic><topic>Phototherapy - methods</topic><topic>photothermal therapy</topic><topic>Physics</topic><topic>Polyethylenimine</topic><topic>Ribonucleic acids</topic><topic>RNA, Small Interfering - administration & dosage</topic><topic>RNA, Small Interfering - chemistry</topic><topic>RNA, Small Interfering - genetics</topic><topic>siRNA</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. 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Healthcare Mater</addtitle><date>2014-10</date><risdate>2014</risdate><volume>3</volume><issue>10</issue><spage>1629</spage><epage>1637</epage><pages>1629-1637</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface‐engineered Au NRs with polyethylenimine are synthesized using a layer‐by‐layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near‐infrared (NIR) light, causing heat‐induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
Multifunctional polyethylenimine (PEI)–gold nanorods (Au NRs) are designed for delivery of small interfering RNA (siRNA) and thermal therapy. This platform shows anticancer activity, through simultaneous thermal ablation and suppression of oncogene expression. miRNA, messenger RNA; NIR, near infrared.</abstract><cop>Weinheim</cop><pub>Blackwell Publishing Ltd</pub><pmid>24692076</pmid><doi>10.1002/adhm.201400103</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anticancer properties Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - therapy Cancer Cell Line, Tumor Cross-disciplinary physics: materials science rheology Drug Delivery Systems - methods Exact sciences and technology Female Gene Silencing Genes Genetic Therapy - methods Gold Gold - administration & dosage Gold - chemistry gold nanorods Humans Hyperthermia, Induced - methods layer-by-layer assembly Macrophages - metabolism Materials science Medical research Medical sciences Mice Nanorods Nanoscale materials and structures: fabrication and characterization Nanotubes - chemistry Phototherapy - methods photothermal therapy Physics Polyethylenimine Ribonucleic acids RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry RNA, Small Interfering - genetics siRNA Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Therapy |
| title | Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy |
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