Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication

Trans sodium crocetinate (TSC) is a synthetic carotenoid that improves the diffusion of oxygen in animal models of ischemia/hypoxia. This study evaluated multiple doses of TSC in patients with peripheral artery disease (PAD) and hypothesized that a preliminary dose–response relationship could be ide...

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Veröffentlicht in:	Vascular medicine (London, England) England), 2011-10, Vol.16 (5), p.346-353
Hauptverfasser:	Mohler, Emile R, Gainer, John L, Whitten, Kim, Eraso, Luis H, Thanaporn, Porama Koy, Bauer, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Ankle Brachial Index Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cohort Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Drug Double-Blind Method Exercise - physiology Exercise Test Female Humans Injections, Intravenous Intermittent Claudication - drug therapy Intermittent Claudication - physiopathology Male Medical sciences Middle Aged Peripheral Arterial Disease - drug therapy Peripheral Arterial Disease - physiopathology Pharmacology. Drug treatments Surveys and Questionnaires Time Factors Treatment Outcome Vasodilator agents. Cerebral vasodilators Vitamin A - administration & dosage Vitamin A - adverse effects Vitamin A - analogs & derivatives Walking
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