Dutasteride reduces alcohol’s sedative effects in men in a human laboratory setting and reduces drinking in the natural environment

Rationale Preclinical studies support the hypothesis that endogenous neuroactive steroids mediate some effects of alcohol. Objectives The aim of this study was to examine the effect of dutasteride inhibition of 5α-reduced neuroactive steroid production on subjective responses to alcohol in adult men...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychopharmacology 2014-09, Vol.231 (17), p.3609-3618
Hauptverfasser:	Covault, Jonathan, Pond, Timothy, Feinn, Richard, Arias, Albert J., Oncken, Cheryl, Kranzler, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors - therapeutic use Adult Alcohol Drinking - drug therapy Alcohol Drinking - genetics Alcohol Drinking - psychology Alcoholism Androstane-3,17-diol - blood Azasteroids - therapeutic use Biomedical and Life Sciences Biomedicine Central Nervous System Depressants - antagonists & inhibitors Central Nervous System Depressants - pharmacology Cross-Over Studies Dosage and administration Dose-Response Relationship, Drug Double-Blind Method Drug interactions Dutasteride Environment Ethanol - antagonists & inhibitors Ethanol - pharmacology Human subjects Humans Identification and classification Male Middle Aged Neurology Neurosciences Original Investigation Pharmacology/Toxicology Prevention Psychiatry Psychopharmacology Receptors, GABA-A - genetics Steroids Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!