Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two...

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Veröffentlicht in:	Retrovirology 2014-09, Vol.11 (1), p.69-69, Article 69
Hauptverfasser:	Ritchie, Adam John, Cai, Fangping, Smith, Nicola M G, Chen, Sheri, Song, Hongshuo, Brackenridge, Simon, Abdool Karim, Salim S, Korber, Bette T, McMichael, Andrew J, Gao, Feng, Goonetilleke, Nilu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acute Disease acute infection Adult AIDS Analysis BASIC BIOLOGICAL SCIENCES CD8-Positive T-Lymphocytes - immunology Colleges & universities Development and progression Genetic aspects Genomes Health aspects HIV HIV Infections - immunology HIV-1 HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Immune Evasion immunodominance Immunology Infections Laboratories Lymphocytes Male Mathematical models multiple infection Mutation Physiological aspects Population recombination Recombination, Genetic T cell virology Virus diseases Virus Replication Viruses
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