Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection
A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two...
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| Veröffentlicht in: | Retrovirology 2014-09, Vol.11 (1), p.69-69, Article 69 |
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| creator | Ritchie, Adam John Cai, Fangping Smith, Nicola M G Chen, Sheri Song, Hongshuo Brackenridge, Simon Abdool Karim, Salim S Korber, Bette T McMichael, Andrew J Gao, Feng Goonetilleke, Nilu |
| description | A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.
Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.
Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses. |
| doi_str_mv | 10.1186/s12977-014-0069-9 |
| format | Article |
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Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.
Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.</description><identifier>ISSN: 1742-4690</identifier><identifier>EISSN: 1742-4690</identifier><identifier>DOI: 10.1186/s12977-014-0069-9</identifier><identifier>PMID: 25212771</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acquired immune deficiency syndrome ; Acute Disease ; acute infection ; Adult ; AIDS ; Analysis ; BASIC BIOLOGICAL SCIENCES ; CD8-Positive T-Lymphocytes - immunology ; Colleges & universities ; Development and progression ; Genetic aspects ; Genomes ; Health aspects ; HIV ; HIV Infections - immunology ; HIV-1 ; HIV-1 - genetics ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Immune Evasion ; immunodominance ; Immunology ; Infections ; Laboratories ; Lymphocytes ; Male ; Mathematical models ; multiple infection ; Mutation ; Physiological aspects ; Population ; recombination ; Recombination, Genetic ; T cell ; virology ; Virus diseases ; Virus Replication ; Viruses</subject><ispartof>Retrovirology, 2014-09, Vol.11 (1), p.69-69, Article 69</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Ritchie et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Ritchie et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-c58888c87bfca6632b0b41559b5b7c6466932478439c3ad83e8e5fc1596cfa5d3</citedby><cites>FETCH-LOGICAL-c591t-c58888c87bfca6632b0b41559b5b7c6466932478439c3ad83e8e5fc1596cfa5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180588/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180588/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25212771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1626906$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ritchie, Adam John</creatorcontrib><creatorcontrib>Cai, Fangping</creatorcontrib><creatorcontrib>Smith, Nicola M G</creatorcontrib><creatorcontrib>Chen, Sheri</creatorcontrib><creatorcontrib>Song, Hongshuo</creatorcontrib><creatorcontrib>Brackenridge, Simon</creatorcontrib><creatorcontrib>Abdool Karim, Salim S</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>McMichael, Andrew J</creatorcontrib><creatorcontrib>Gao, Feng</creatorcontrib><creatorcontrib>Goonetilleke, Nilu</creatorcontrib><creatorcontrib>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</creatorcontrib><title>Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection</title><title>Retrovirology</title><addtitle>Retrovirology</addtitle><description>A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.
Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.
Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acute Disease</subject><subject>acute infection</subject><subject>Adult</subject><subject>AIDS</subject><subject>Analysis</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Colleges & universities</subject><subject>Development and progression</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune Evasion</subject><subject>immunodominance</subject><subject>Immunology</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mathematical models</subject><subject>multiple infection</subject><subject>Mutation</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>recombination</subject><subject>Recombination, Genetic</subject><subject>T cell</subject><subject>virology</subject><subject>Virus diseases</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>1742-4690</issn><issn>1742-4690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptUttqFTEUHUSxtfoBvsigLwWZmvvlRSinagsFRaqvIZPZ06bMJMfJjODfu4dzrK2YQK5rr6wsVlW9pOSEUqPeFcqs1g2hoiFE2cY-qg6pFqwRypLH99YH1bNSbgnh1BDztDpgklGmNT2svnyFkMc2Jj_HnJoRuuhn6GoowW-h7qc81tspjn76VW_OzNv6qg4wDKWOqfZhmaE-v_jeUNz2EFaK59WT3g8FXuzno-rbxw9Xm_Pm8vOni83pZROkpTOOBlswuu2DV4qzlrSCSmlb2eqghFKWM6GN4DZw3xkOBmQfqLQq9F52_Kh6v-PdLi2qDpDmyQ9ur9VlH93DmxRv3HX-6QR6gI8jwesdQS5zdCXEGcJNyCnhPxxVDG1TCDrevzLlHwuU2Y2xrAb4BHkpiFNEScYsR-ibf6C3eZkSeoAoKixlUqq_qGs_gEPXMooLK6k7ldwqTYxkiDr5Dwp7B2NEjdBHPH9QQHcFYcqlTNDfGUGJW7PidllxmBW3ZsVZrHl138G7ij_h4L8BOy22bQ</recordid><startdate>20140912</startdate><enddate>20140912</enddate><creator>Ritchie, Adam John</creator><creator>Cai, Fangping</creator><creator>Smith, Nicola M G</creator><creator>Chen, Sheri</creator><creator>Song, Hongshuo</creator><creator>Brackenridge, Simon</creator><creator>Abdool Karim, Salim S</creator><creator>Korber, Bette T</creator><creator>McMichael, Andrew J</creator><creator>Gao, Feng</creator><creator>Goonetilleke, Nilu</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20140912</creationdate><title>Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection</title><author>Ritchie, Adam John ; Cai, Fangping ; Smith, Nicola M G ; Chen, Sheri ; Song, Hongshuo ; Brackenridge, Simon ; Abdool Karim, Salim S ; Korber, Bette T ; McMichael, Andrew J ; Gao, Feng ; Goonetilleke, Nilu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-c58888c87bfca6632b0b41559b5b7c6466932478439c3ad83e8e5fc1596cfa5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acute Disease</topic><topic>acute infection</topic><topic>Adult</topic><topic>AIDS</topic><topic>Analysis</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Colleges & universities</topic><topic>Development and progression</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>HIV</topic><topic>HIV Infections - immunology</topic><topic>HIV-1</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune Evasion</topic><topic>immunodominance</topic><topic>Immunology</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mathematical models</topic><topic>multiple infection</topic><topic>Mutation</topic><topic>Physiological aspects</topic><topic>Population</topic><topic>recombination</topic><topic>Recombination, Genetic</topic><topic>T cell</topic><topic>virology</topic><topic>Virus diseases</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ritchie, Adam John</creatorcontrib><creatorcontrib>Cai, Fangping</creatorcontrib><creatorcontrib>Smith, Nicola M G</creatorcontrib><creatorcontrib>Chen, Sheri</creatorcontrib><creatorcontrib>Song, Hongshuo</creatorcontrib><creatorcontrib>Brackenridge, Simon</creatorcontrib><creatorcontrib>Abdool Karim, Salim S</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>McMichael, Andrew J</creatorcontrib><creatorcontrib>Gao, Feng</creatorcontrib><creatorcontrib>Goonetilleke, Nilu</creatorcontrib><creatorcontrib>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Retrovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ritchie, Adam John</au><au>Cai, Fangping</au><au>Smith, Nicola M G</au><au>Chen, Sheri</au><au>Song, Hongshuo</au><au>Brackenridge, Simon</au><au>Abdool Karim, Salim S</au><au>Korber, Bette T</au><au>McMichael, Andrew J</au><au>Gao, Feng</au><au>Goonetilleke, Nilu</au><aucorp>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection</atitle><jtitle>Retrovirology</jtitle><addtitle>Retrovirology</addtitle><date>2014-09-12</date><risdate>2014</risdate><volume>11</volume><issue>1</issue><spage>69</spage><epage>69</epage><pages>69-69</pages><artnum>69</artnum><issn>1742-4690</issn><eissn>1742-4690</eissn><abstract>A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.
Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.
Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25212771</pmid><doi>10.1186/s12977-014-0069-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Acute Disease acute infection Adult AIDS Analysis BASIC BIOLOGICAL SCIENCES CD8-Positive T-Lymphocytes - immunology Colleges & universities Development and progression Genetic aspects Genomes Health aspects HIV HIV Infections - immunology HIV-1 HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Humans Immune Evasion immunodominance Immunology Infections Laboratories Lymphocytes Male Mathematical models multiple infection Mutation Physiological aspects Population recombination Recombination, Genetic T cell virology Virus diseases Virus Replication Viruses |
| title | Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection |
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