Folding Dynamics and Pathways of the Trp-Cage Miniproteins

Using alternate measures of fold stability for a wide variety of Trp-cage mutants has raised the possibility that prior dynamics T-jump measures may not be reporting on complete cage formation for some species. NMR relaxation studies using probes that only achieve large chemical shift difference fro...

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Veröffentlicht in:	Biochemistry (Easton) 2014-09, Vol.53 (38), p.6011-6021
Hauptverfasser:	Byrne, Aimee, Williams, D. Victoria, Barua, Bipasha, Hagen, Stephen J, Kier, Brandon L, Andersen, Niels H
Format:	Artikel
Sprache:	eng
Schlagworte:	hydrogen bonding Magnetic Resonance Spectroscopy mutants Mutation nuclear magnetic resonance spectroscopy Protein Conformation Protein Folding
Online-Zugang:	Volltext
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