Conformational change in transfer RNA is an early indicator of acute cellular damage

Tissue damage by oxidative stress is a key pathogenic mechanism in various diseases, including AKI and CKD. Thus, early detection of oxidative tissue damage is important. Using a tRNA-specific modified nucleoside 1-methyladenosine (m1A) antibody, we show that oxidative stress induces a direct confor...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2014-10, Vol.25 (10), p.2316-2326
Hauptverfasser:	Mishima, Eikan, Inoue, Chisako, Saigusa, Daisuke, Inoue, Ryusuke, Ito, Koki, Suzuki, Yusuke, Jinno, Daisuke, Tsukui, Yuri, Akamatsu, Yosuke, Araki, Masatake, Araki, Kimi, Shimizu, Ritsuko, Shinke, Haruka, Suzuki, Takehiro, Takeuchi, Yoichi, Shima, Hisato, Akiyama, Yasutoshi, Toyohara, Takafumi, Suzuki, Chitose, Saiki, Yoshikatu, Tominaga, Teiji, Miyagi, Shigehito, Kawagisihi, Naoki, Soga, Tomoyoshi, Ohkubo, Takayoshi, Yamamura, Kenichi, Imai, Yutaka, Masuda, Satohiro, Sabbisetti, Venkata, Ichimura, Takaharu, Mount, David B, Bonventre, Joseph V, Ito, Sadayoshi, Tomioka, Yoshihisa, Itoh, Kunihiko, Abe, Takaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - diagnosis Acute Kidney Injury - metabolism Adenosine - analogs & derivatives Adenosine - immunology Aged Animals Apoptosis Basic Research Case-Control Studies DNA Damage Female Humans Japan - epidemiology Male Mice, Inbred C57BL Mice, Knockout Middle Aged Molecular Conformation Oxidative Stress Rats, Wistar Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - mortality RNA, Transfer - chemistry RNA, Transfer - immunology RNA, Transfer - metabolism
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