The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption

The cytoskeleton of human trabecular meshwork (HTM) cells is known to be altered in glaucoma and has been hypothesized to reduce outflow facility through contracting the HTM tissue. Latrunculin B (Lat-B) and Rho-associated protein kinase (ROCK) inhibitors disrupt the actin cytoskeleton and are in cl...

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Veröffentlicht in:	Experimental cell research 2014-10, Vol.328 (1), p.164-171
Hauptverfasser:	Murphy, Kaitlin C., Morgan, Joshua T., Wood, Joshua A., Sadeli, Adeline, Murphy, Christopher J., Russell, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Amides - pharmacology Antihypertensive Agents - pharmacology Arrays Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Physiological Phenomena Cells Cells, Cultured Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - metabolism Humans Image Processing, Computer-Assisted Latrunculin B Pyridines - pharmacology rho-Associated Kinases - antagonists & inhibitors Rho-associated protein kinase Thiazolidines - pharmacology Trabecular Meshwork Trabecular Meshwork - cytology Trabecular Meshwork - drug effects
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