Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy

Background Peroxynitrite, a product of the reaction of superoxide with nitric oxide, causes oxidative stress with concomitant inactivation of enzymes, poly(ADP‐ribosylation), mitochondrial dysfunction and impaired stress signalling, as well as protein nitration. In this study, we sought to determine...

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Veröffentlicht in:	Diabetes/metabolism research and reviews 2014-11, Vol.30 (8), p.669-678
Hauptverfasser:	Stavniichuk, Roman, Shevalye, Hanna, Lupachyk, Sergey, Obrosov, Alexander, Groves, John T., Obrosova, Irina G., Yorek, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidants Antioxidants - adverse effects Antioxidants - therapeutic use Behavior, Animal - drug effects Catechin - adverse effects Catechin - analogs & derivatives Catechin - therapeutic use Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetic Neuropathies - metabolism Diabetic Neuropathies - pathology Diabetic Neuropathies - physiopathology Diabetic Neuropathies - prevention & control diabetic neuropathy Epidermis - drug effects Epidermis - innervation Epidermis - metabolism Epidermis - pathology Ferric Compounds - adverse effects Ferric Compounds - therapeutic use Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Male Metalloporphyrins - adverse effects Metalloporphyrins - therapeutic use Mice, Inbred C57BL Motor Neurons - drug effects Motor Neurons - metabolism Motor Neurons - pathology Nerve Tissue Proteins - metabolism Neural Conduction - drug effects nitrosative stress oxidative stress Oxidative Stress - drug effects Peripheral Nervous System - drug effects Peripheral Nervous System - metabolism Peripheral Nervous System - pathology Peripheral Nervous System - physiopathology peroxynitrite Peroxynitrous Acid - antagonists & inhibitors Peroxynitrous Acid - metabolism Reaction Time - drug effects Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Sensory Receptor Cells - pathology superoxide
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