Ketone bodies as signaling metabolites

Highlights • Ketone bodies have signaling functions as well as being a mobile source of cellular energy. • Ketone bodies inhibit histone deacetylases and control gene transcription. • Histone deacetylase function is implicated in the regulation of aging. • Ketone bodies may link environmental cues s...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2014-01, Vol.25 (1), p.42-52
Hauptverfasser:	Newman, John C, Verdin, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - metabolism acetylation Aging - physiology Animals Caloric Restriction calorie restriction Endocrinology & Metabolism epigenetics HDAC Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Humans Ketone Bodies - metabolism longevity Monocarboxylic Acid Transporters - metabolism Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Highlights • Ketone bodies have signaling functions as well as being a mobile source of cellular energy. • Ketone bodies inhibit histone deacetylases and control gene transcription. • Histone deacetylase function is implicated in the regulation of aging. • Ketone bodies may link environmental cues such as diet to the regulation of aging.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2013.09.002