Development of a Fluorescence Assay for the Characterization of Brevenal Binding to Rat Brain Synaptosomes

The marine dinoflagellate Karenia brevis produces a family of neurotoxins known as brevetoxins. Brevetoxins elicit their effects by binding to and activating voltage-sensitive sodium channels (VSSCs) in cell membranes. K. brevis also produces brevenal, a brevetoxin antagonist, which is able to inhib...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-09, Vol.77 (9), p.2014-2020
Hauptverfasser:	McCall, Jennifer R, Goodman, Allan J, Jacocks, Henry M, Thompson, Alysha M, Baden, Daniel G, Bourdelais, Andrea J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists binding sites Binding, Competitive brain Brain - drug effects brevetoxins cell membranes Dinoflagellida - chemistry Ethers - pharmacology Fluorescence Karenia brevis Ligands Molecular Structure neurotoxins Neurotoxins - pharmacology Polymers - pharmacology radioactive waste Rats sodium channels synaptosomes Synaptosomes - drug effects Voltage-Gated Sodium Channels - drug effects
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