The Spatiotemporal Dynamics of Chromatin Protein HP1α Is Essential for Accurate Chromosome Segregation during Cell Division

Heterochromatin protein 1α (HP1α) is involved in regulation of chromatin plasticity, DNA damage repair, and centromere dynamics. HP1α detects histone dimethylation and trimethylation of Lys-9 via its chromodomain. HP1α localizes to heterochromatin in interphase cells but is liberated from chromosoma...

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Veröffentlicht in:	The Journal of biological chemistry 2014-09, Vol.289 (38), p.26249-26262
Hauptverfasser:	Chu, Lingluo, Huo, Yuda, Liu, Xing, Yao, Phil, Thomas, Kelwyn, Jiang, Hao, Zhu, Tongge, Zhang, Guanglan, Chaudhry, Maryam, Adams, Gregory, Thompson, Winston, Dou, Zhen, Jin, Changjiang, He, Ping, Yao, Xuebiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Cycle Proteins - metabolism Centromere - metabolism Chromosomal Proteins, Non-Histone - metabolism Chromosome Segregation Chromosomes, Human - metabolism HEK293 Cells HeLa Cells Heterochromatin - metabolism Humans Kinetochores - metabolism Methyltransferases - metabolism Mitosis Protein Transport Repressor Proteins - metabolism Spindle Apparatus - metabolism
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