Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels

Autophagy is a tightly regulated lysosomal degradation pathway for maintaining cellular homeostasis and responding to stresses. Beclin 1 and its interacting proteins, including the class III phosphatidylinositol-3 kinase Vps34, play crucial roles in autophagy regulation in mammals. We identified nuc...

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Veröffentlicht in:	The Journal of biological chemistry 2014-09, Vol.289 (38), p.26021-26037
Hauptverfasser:	Zhong, Yu, Morris, Deanna H., Jin, Lin, Patel, Mittul S., Karunakaran, Senthil K., Fu, You-Jun, Matuszak, Emily A., Weiss, Heidi L., Chait, Brian T., Wang, Qing Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - metabolism Amino Acid Sequence Apoptosis Regulatory Proteins - metabolism Autophagy Autophagy-Related Proteins Beclin-1 Cell Biology Class III Phosphatidylinositol 3-Kinases - metabolism Green Fluorescent Proteins - biosynthesis Hep G2 Cells Humans Membrane Proteins - metabolism Molecular Sequence Data Multiprotein Complexes - metabolism Phagosomes - metabolism Phosphatidylinositol Phosphates - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Interaction Maps Protein Transport Recombinant Fusion Proteins - biosynthesis Trans-Activators - chemistry Trans-Activators - physiology
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