Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism

Anti-tumor immune responses have been linked to the regulated release of ATP from apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in nearby leukocytes. We used the Jurkat T cell acute lymphocytic leukemia model to characterize the role of pannexin-1 (Panx1) channels in the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2014-09, Vol.289 (39), p.27246-27263
Hauptverfasser:	Boyd-Tressler, Andrea, Penuela, Silvia, Laird, Dale W., Dubyak, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - genetics Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Caspase 3 - genetics Caspase 3 - metabolism Caspase Inhibitors - pharmacology Connexins - genetics Connexins - metabolism Humans Jurkat Cells Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!