Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia

The most common form of newborn chronic lung disease, bronchopulmonary dysplasia (BPD), is thought to be caused by oxidative disruption of lung morphogenesis, which results in decreased pulmonary vasculature and alveolar simplification. Although cellular redox status is known to regulate cellular pr...

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Veröffentlicht in:	Free radical biology & medicine 2014-10, Vol.75, p.167-177
Hauptverfasser:	Floen, Miranda J., Forred, Benjamin J., Bloom, Elliot J., Vitiello, Peter F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchopulmonary Dysplasia - embryology Bronchopulmonary Dysplasia - pathology Buthionine Sulfoximine - pharmacology Cell death Cell Line, Tumor Cell Survival Free radicals Glutathione - biosynthesis Glutathione - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Hyperoxia Hyperoxia - metabolism Lung - blood supply Lung - embryology Oxidation-Reduction Oxygen - pharmacology Peroxiredoxins - metabolism Redox signaling RNA Interference RNA, Small Interfering Signal Transduction Thioredoxin-1 Thioredoxin-Disulfide Reductase - metabolism Thioredoxins - biosynthesis Thioredoxins - genetics Thioredoxins - metabolism
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